γδ T cells turn the tables on immune-evasive colon cancer

Coffelt, S. B. and Suzuki, T. (2023) γδ T cells turn the tables on immune-evasive colon cancer. Med, 4(3), pp. 141-142. (doi: 10.1016/j.medj.2023.02.007)

Abstract

Why is checkpoint blockade immunotherapy still effective in tumors that are unrecognizable to CD8+ T cells? In a recent study published in Nature, de Vries et al.1 provide evidence that the lesser-known γδ T cell population may mediate beneficial responses to immune checkpoint blockade when cancer cells lose HLA expression.

• Item Type: Articles
• Additional Information: Our lab receives funding from the Annie McNab Bequest (CRUK Beatson Institute), Breast Cancer Now (2018JulPR1101, 2019DecPhD1349, 2019DecPR1424), Cancer Research Institute (CLIP award), Cancer Research UK (RCCCEA-Nov21\100003, EDDPGM-Nov21\100001, DRCNPG-Jun22\100007), Pancreatic Cancer Research and Worldwide Cancer Research (22-0135).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Coffelt, Dr Seth
• Authors: Coffelt, S. B., and Suzuki, T.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Med
• Publisher: Cell Press
• ISSN: 2666-6340
• ISSN (Online): 2666-6340
• Copyright Holders: Copyright © 2023 Elsevier Inc.
• First Published: First published in Med 4(3): 141-142
• Publisher Policy: Reproduced in accordance with the publisher copyright policy

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
303457		Regulation of IL-17-producing T cells in Breast Cancer Metastasis	Seth Coffelt	Breast Cancer Now (BRCANNOW)	2018JulPR1101	CS - Beatson Institute for Cancer Research
308295		Targeting triple negative breast cancer with gamma delta T cells	Seth Coffelt	Breast Cancer Now (BRCANNOW)	2019DecPhD1349	CS - Beatson Institute for Cancer Research