Osmosis effect on protein sustained release of Agarose hydrogel for anti-friction performance

Hafezi, M., Qin, L., Mahmoodi, P. and Guangneng, D. (2019) Osmosis effect on protein sustained release of Agarose hydrogel for anti-friction performance. Tribology International, 132, pp. 108-117. (doi: 10.1016/j.triboint.2018.12.013)

Abstract

Agarose hydrogel as an efficient carrier for protein model has been considered to optimize the lubrication of artificial hip joints. Elevating the effectiveness of lubricant to reduce frictional coefficient and wear debris to prolong life time of prosthesis is a main goal. Various biological solvents, such as sodium chloride (NaCl) solution, simulated body fluid (SBF), phosphate buffer solution (PBS) and deionized water, have been investigated to achieve the best structure for polymeric network during the hydrogel preparation process. Results proof that SBF is able to provide sustained release with 38% reduction rate of frictional coefficient to demonstrate sufficient strength of the polymer chains. Novelty of the present work is focusing on the anti-friction performance of hydrogel protein delivery system designed for medical or pharmaceutical applications.

• Item Type: Articles
• Additional Information: This work was financially supported by National Natural Science Foundation of China (51175406 and 51605370), Postdoctrol Science Foundation of Shaanxi Province (2017BSHEDZZ122), China Postdoctrol Science Foundation funded project(2016M602802), the Natural Science Found of Shaanxi Province (2017JQ5009) and the Fundamental Research Funds for the Central University.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hafezi, Dr Mahshid
• Authors: Hafezi, M., Qin, L., Mahmoodi, P., and Guangneng, D.
• College/School: College of Science and Engineering > School of Engineering > Systems Power and Energy
• Journal Name: Tribology International
• Publisher: Elsevier
• ISSN: 0301-679X
• ISSN (Online): 1879-2464
• Published Online: 17 December 2018