Presence of retinopathy and incident kidney and cardiovascular events in type 2 diabetes with normoalbuminuria – a post-hoc analysis of the PRIORITY randomized clinical trial

Rotbain Curovic, V. et al. (2023) Presence of retinopathy and incident kidney and cardiovascular events in type 2 diabetes with normoalbuminuria – a post-hoc analysis of the PRIORITY randomized clinical trial. Journal of Diabetes and its Complications, 37(4), 108433. (doi: 10.1016/j.jdiacomp.2023.108433) (PMID:36841085)

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Abstract

Aims: Baseline diabetic retinopathy (DR) and risk of development of microalbuminuria, kidney function decline, and cardiovascular events (CVEs) in type 2 diabetes. Methods: Post-hoc analysis of the PRIORITY study including 1758 persons with type 2 diabetes and normoalbuminuria followed for a median of 2.5 (IQR: 2.0–3.0) years. DR diagnosis included non-proliferative and proliferative abnormalities, macular oedema, or prior laser treatment. Cox models were fitted to investigate baseline DR presence with development of persistent microalbuminuria (urinary albumin-creatinine ratio > 30 mg/g); chronic kidney disease (CKD) G3 (eGFR <60 mL/min/1.73m2); and CVE. Models were adjusted for relevant risk factors. Results: At baseline, 304 (17.3 %) had DR. Compared to persons without DR, they were older (mean ± SD: 62.7 ± 7.7 vs 61.4 ± 8.3 years, p = 0.019), had longer diabetes duration (17.9 ± 8.4 vs. 10.6 ± 7.0 years, p < 0.001), and higher HbA1c (62 ± 13 vs. 56 ± 12 mmol/mol, p < 0.001). The adjusted hazard ratios of DR at baseline for development of microalbuminuria (n = 197), CKD (n = 166), and CVE (n = 64) were: 1.50 (95%CI: 1.07, 2.11), 0.87 (95%CI: 0.56, 1.34), and 2.61 (95%CI: 1.44, 4.72), compared to without DR. Conclusions: Presence of DR in normoalbuminuric type 2 diabetes was associated with an increased risk of developing microalbuminuria and CVE, but not with kidney function decline.

Item Type:Articles
Additional Information:The PRIORITY study was funded by the European Union Seventh Framework Programme (FP7/20072-013) under grant agreement number 279277. The present study was also carried out in with funding from the European Union Horizon 2020 research programme DC-ren (Grant No 848011).
Keywords:Type 2 diabetes, diabetic retinopathy, chronic kidney disease, albuminuria, cardiovascular disease, risk stratification.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mischak, Professor Harald and Delles, Professor Christian and Currie, Dr Gemma and Petrie, Professor John
Authors: Rotbain Curovic, V., Tofte, N., Lindhardt, M., Adamova, K., Bakker, S. J.L., Beige, J., Beulens, J. W.J., Birkenfeld, A. L., Currie, G., Delles, C., Dimos, I., Francová, L., Frimodt-Møller, M., Girman, P., Göke, R., Hansen, T. W., Havrdova, T., Kooy, A., Laverman, G. D., Mischak, H., Navis, G., Nijpels, G., Noutsou, M., Ortiz, A., Parvanova, A., Persson, F., Petrie, J. R., Ruggenenti, P. L., Rutters, F., Rychlík, I., Siwy, J., Spasovski, G., Speeckaert, M., Trillin, M., Zürbig, P., von der Leyen, H., Rossing, P., and PRIORITY Study Group,
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
Journal Name:Journal of Diabetes and its Complications
Publisher:Elsevier
ISSN:1056-8727
ISSN (Online):1873-460X
Published Online:18 February 2023
Copyright Holders:Copyright © 2023 Elsevier Inc.
First Published:First published in Journal of Diabetes and its Complications 37(4): 108433
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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