Frailty index as a predictor of mortality in middle-aged and older people: a prospective analysis of Chilean adults

Diaz-Toro, F. et al. (2023) Frailty index as a predictor of mortality in middle-aged and older people: a prospective analysis of Chilean adults. International Journal of Environmental Research and Public Health, 20(2), 1195. (doi: 10.3390/ijerph20021195) (PMID:36673951) (PMCID:PMC9859421)

Abstract

We aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged ≥ 35 from the Chilean National Health Survey 2009–2010. Mortality was determined through linkage with the Chilean Civil Registry and Identification. A 36-item frailty index (FI) was used to assess the frailty status. Associations between frailty status and all-cause mortality were assessed using Kaplan–Meier and Cox proportional hazard models adjusted for sociodemographic and lifestyle factors. A non-linear association was investigated using penalized cubic splines fitted in the Cox models. During an 8.9 median follow-up (interquartile range of 8.6–9.0), 308 individuals died (11.5%). Lower survival rates were observed in frail individuals compared to pre-frail and robust people (log-rank < 0.001). Compared with robust individuals, frail people had a higher mortality risk (HR: 2.35 [95% CI: 1.57 to 3.51]). Frail middle-aged individuals had a higher risk of dying independently of major risk factors.

• Item Type: Articles
• Keywords: Frailty, mortality, middle-aged, Chile.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Celis, Dr Carlos and Petermann-Rocha, Mrs Fanny and Parra, Solange
• Authors: Diaz-Toro, F., Nazar, G., Troncoso, C., Concha-Cisternas, Y., Leiva-Ordoñez, A. M., Martinez-Sanguinetti, M. A., Parra-Soto, S., Lasserre-Laso, N., Cigarroa, I., Mardones, L., Vásquez-Gómez, J., Petermann-Rocha, F., Diaz-Martinez, X., and Celis-Morales, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: International Journal of Environmental Research and Public Health
• Publisher: MDPI
• ISSN: 1661-7827
• ISSN (Online): 1660-4601
• Published Online: 10 January 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in International Journal of Environmental Research and Public Health 20(2): 1195
• Publisher Policy: Reproduced under a Creative Commons License