Exercise and calcium in the heart

Kemi, O. J. (2023) Exercise and calcium in the heart. Current Opinion in Physiology, 32, 100644. (doi: 10.1016/j.cophys.2023.100644)

Abstract

Cardiomyocyte Ca2+ dictates cardiac contraction, via excitation-contraction coupling and excitation-transcription coupling. Adaptation to these processes also majorly contributes to enhanced contractile function and capacity following exercise training. Cytoplasmic Ca2+ release controls sarcomeric contraction, with important modulation by the voltage-sensitive plasma membrane L-type Ca2+ channel and the Ryanodine receptor, as well as the Sarcoplasmic reticulum Ca2+ ATPase. Exercise training increases and enhances these excitation-contraction coupling sub-processes, in a manner that increases and enhances cardiac contraction. Also, adaptation to exercise training further includes myofilament Ca2+ sensitization. Then there are several aspects linked to post-exercise training cardiomyocyte Ca2+ handling that remain speculative and inconclusive, but could if proven true be of special importance. This includes Ca2+-linked muscle-specific gene transcription to alter cell architecture and size, and it includes the scenario whereby Ca2+ cycling and adaptations may alter arrhythmogenicity. These aspects of cardiac Ca2+ adaptations to exercise training are discussed in this review article.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kemi, Dr Ole

Creator Roles

Kemi, O.: Conceptualization, Writing – review and editing

• Authors: Kemi, O. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Current Opinion in Physiology
• Publisher: Elsevier
• ISSN: 2468-8681
• ISSN (Online): 2468-8673
• Published Online: 09 February 2023
• Copyright Holders: Copyright © 2023 The Author
• First Published: First published in Current Opinion in Physiology 32: 100644
• Publisher Policy: Reproduced under a Creative Commons License