Synthesis of the CDF ring system of hexacyclinic acid

Audic, A. and Prunet, J. (2023) Synthesis of the CDF ring system of hexacyclinic acid. Synthesis, 55(15), pp. 2333-2342. (doi: 10.1055/a-2022-1809)

Abstract

Diverse approaches to prepare the nine-membered ring precursor of the DEF fragment of hexacyclinic acid are described, culminating in the synthesis of the CDF ring system of this natural product. The key steps are a Michael addition/elimination sequence and an original intramolecular Tsuji-Trost reaction of an enol with an allylic alcohol.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Prunet, Dr Joelle and Audic, Alexandre Baptiste Robert
• Authors: Audic, A., and Prunet, J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Synthesis
• Publisher: Thieme Publishing
• ISSN: 0039-7881
• ISSN (Online): 1437-210X
• Published Online: 30 January 2023
• Copyright Holders: Copyright © 2023 Thieme
• First Published: First published in Synthesis 55(15):2333-2342
• Publisher Policy: Reproduced in accordance with the publisher copyright policy

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Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
190490		Engineering and Physical Sciences Doctoral Training Grant 2012-16	Mary Beth Kneafsey	Engineering and Physical Sciences Research Council (EPSRC)	EP/K503058/1	Research and Innovation Services