Guselnikova, O., Elashnikov, R., Svorcik, V., Kartau, M., Gilroy, C., Gadegaard, N. , Kadodwala, M. , Karimullah, A. S. and Lyutakov, O. (2023) Coupling of plasmonic hot spots with shurikens for superchiral SERS-based enantiomer recognition. Nanoscale Horizons, 8(4), pp. 499-508. (doi: 10.1039/D3NH00008G) (PMID:36752733)
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Abstract
Detection of enantiomers is a challenging problem in drug development as well as environmental and food quality monitoring where traditional optical detection methods suffer from low signals and sensitivity. Application of surface enhanced Raman scattering (SERS) for enantiomeric discrimination is a powerful approach for the analysis of optically active small organic or large biomolecules. In this work, we proposed the coupling of disposable chiral plasmonic shurikens supporting the chiral near-field distribution with SERS active silver nanoclusters for enantio-selective sensing. As a result of the plasmonic coupling, significant difference in SERS response of optically active analytes is observed. The observations are studied by numerical simulations and it is hypothesized that the silver particles are being excited by superchiral fields generated at the surface inducing additional polarizations in the probe molecules. The plasmon coupling phenomena was found to be extremely sensitive to slight variations in shuriken geometry, silver nanostructured layer parameters, and SERS excitation wavelength(s). Designed structures were able to discriminate cysteine enantiomers at concentrations in the nanomolar range and probe biomolecular chirality, using a common Raman spectrometer within several minutes. The combination of disposable plasmonic substrates with specific near-field polarization can make the SERS enantiomer discrimination a commonly available technique using standard Raman spectrometers.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was financially supported by GACR under the project 20-19353S (OL) and Tomsk Polytechnic University Enhancement program (OG). AK would like to acknowledge support by the UKRI, EPSRC (EP/S001514/1 and EP/S029168/1) and the James Watt Nanofabrication Centre. NG and MK acknowledge support from EPSRC (EP/S012745/1 and EP/S029168/1). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Kartau, Mr Martin and Gilroy, Mr Cameron and Gadegaard, Professor Nikolaj and Kadodwala, Professor Malcolm and Karimullah, Dr Affar |
| Authors: | Guselnikova, O., Elashnikov, R., Svorcik, V., Kartau, M., Gilroy, C., Gadegaard, N., Kadodwala, M., Karimullah, A. S., and Lyutakov, O. |
| College/School: | College of Science and Engineering > School of Chemistry College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Nanoscale Horizons |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 2055-6756 |
| ISSN (Online): | 2055-6764 |
| Published Online: | 31 January 2023 |
| Copyright Holders: | Copyright © 2023 The Royal Society of Chemistry |
| First Published: | First published in Nanoscale Horizons 8(4): 499-508 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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