Manera, M. R., Fiabane, E., Pain, D., Aiello, E. N., Radici, A., Ottonello, M., Padovani, M., Wilson, B. A., Fish, J. and Pistarini, C. (2022) Clinical features and cognitive sequelae in COVID-19: a retrospective study on N=152 patients. Neurological Sciences, 43(1), pp. 45-50. (doi: 10.1007/s10072-021-05744-8) (PMID:34779965) (PMCID:PMC8591589)
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Abstract
Background: The novel human coronavirus (SARS-CoV-2) shows neurotropism and systemically affects the central nervous system (CNS). Cognitive deficits have been indeed reported as both short- and long-term sequelae of SARS-CoV-2 infection. However, the association between these disturbances and background/disease-related clinical features remains elusive. This work aimed at exploring how post-infective cognitive status relates to clinical/treatment outcomes by controlling for premorbid/current risk factors for cognitive deficits. Methods: Cognitive measures (Mini-Mental State Examination, MMSE) of N=152 COVID-19 patient were retrospectively assessed in relation to disease severity, intensive care unit (ICU) admission, steroidal treatment, and occurrence of other viral/bacterial infections by controlling for remote/recent/COVID-19-related risk factors for cognitive deficits (at-risk vs. not-at-risk: Neuro+ vs. Neuro−). Results: Descriptively, impaired MMSE performances were highly prevalent in mild-to-moderate patients (26.3%). ICU-admitted patients made less errors (p=.021) on the MMSE than those not admitted when partialling out risk factors and age—the latter negatively influencing performances. When addressing Neuro− patients only, steroidal treatment appears to improve MMSE scores among those suffering from other infections (p=.025). Discussion: Cognitive sequelae of COVID-19 are likely to arise from a complex interplay between background/clinical premorbid features and disease-related/interventional procedures and outcomes. Mild-to-moderate patients requiring assistive ventilation who however are not admitted to an ICU are more likely to suffer from cognitive deficits—despite their etiology remaining elusive.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Fish, Dr Jessica |
Authors: | Manera, M. R., Fiabane, E., Pain, D., Aiello, E. N., Radici, A., Ottonello, M., Padovani, M., Wilson, B. A., Fish, J., and Pistarini, C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing |
Journal Name: | Neurological Sciences |
Publisher: | Springer |
ISSN: | 1590-1874 |
ISSN (Online): | 1590-3478 |
Published Online: | 15 November 2021 |
Copyright Holders: | Copyright © 2021 Fondazione Società Italiana di Neurologia |
First Published: | First published in Neurological Sciences 43(1):45-50 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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