Dhawan, U. , Tseng, C.-L., Wu, P.-H., Liao, M.-Y., Wang, H.-Y., Wu, K. C.-W. and Chung, R.-J. (2023) Theranostic doxorubicin encapsulated FeAu alloy@metal-organic framework nanostructures enable magnetic hyperthermia and medical imaging in oral carcinoma. Nanomedicine: Nanotechnology, Biology and Medicine, 48, 102652. (doi: 10.1016/j.nano.2023.102652) (PMID:36623714)
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Abstract
Metal-organic frameworks (MOFs) have emerged as attractive candidates in cancer theranostics due to their ability to envelop magnetic nanoparticles, resulting in reduced cytotoxicity and high porosity, enabling chemodrug encapsulation. Here, FeAu alloy nanoparticles (FeAu NPs) are synthesized and coated with MIL-100(Fe) MOFs to fabricate FeAu@MOF nanostructures. We encapsulated Doxorubicin within the nanostructures and evaluated the suitability of this platform for medical imaging and cancer theranostics. FeAu@MOF nanostructures (FeAu@MIL-100(Fe)) exhibited superparamagnetism, magnetic hyperthermia behavior and displayed DOX encapsulation and release efficiency of 69.95 % and 97.19 %, respectively, when stimulated with alternating magnetic field (AMF). In-vitro experiments showed that AMF-induced hyperthermia resulted in 90 % HSC-3 oral squamous carcinoma cell death, indicating application in cancer theranostics. Finally, in an in-vivo mouse model, FeAu@MOF nanostructures improved image contrast, reduced tumor volume by 30-fold and tumor weight by 10-fold, which translated to enhancement in cumulative survival, highlighting the prospect of this platform for oral cancer treatment.
| Item Type: | Articles |
|---|---|
| Additional Information: | The authors are grateful for the financial supports of this research by the Ministry of Science and Technology of Taiwan (MOST 108-2628-E-027-003-MY3; MOST 111-2221-E-027-105), the National Taipei University of Technology-Mackay Memorial Hospital Joint Research Program (NTUT-MMH-108-08, NTUT-MMH-109-04, NTUT-MMH-111-01). |
| Keywords: | Hyperthermia, iron‑gold alloy nanoparticles, oral squamous carcinoma, metal-organic framework, cancer theranostics. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Dhawan, Dr Udesh |
| Creator Roles: | |
| Authors: | Dhawan, U., Tseng, C.-L., Wu, P.-H., Liao, M.-Y., Wang, H.-Y., Wu, K. C.-W., and Chung, R.-J. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Nanomedicine: Nanotechnology, Biology and Medicine |
| Publisher: | Elsevier |
| ISSN: | 1549-9634 |
| ISSN (Online): | 1549-9642 |
| Published Online: | 07 January 2023 |
| Copyright Holders: | Copyright © 2023 Elsevier Inc. |
| First Published: | First published in Nanomedicine: Nanotechnology, Biology and Medicine 48: 102652 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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