Fabrication of biodegradable and biocompatible functional polymers for anti-infection and augmenting wound repair

Deng, S. et al. (2023) Fabrication of biodegradable and biocompatible functional polymers for anti-infection and augmenting wound repair. Polymers, 15(1), 120. (doi: 10.3390/polym15010120) (PMID:36616470)

Abstract

The problem of bacteria-induced infections threatens the lives of many patients. Meanwhile, the misuse of antibiotics has led to a significant increase in bacterial resistance. There are two main ways to alleviate the issue: one is to introduce antimicrobial agents to medical devices to get local drug releasing and alleviating systemic toxicity and resistance, and the other is to develop new antimicrobial methods to kill bacteria. New antimicrobial methods include cationic polymers, metal ions, hydrophobic structures to prevent bacterial adhesion, photothermal sterilization, new biocides, etc. Biodegradable biocompatible synthetic polymers have been widely used in the medical field. They are often used in tissue engineering scaffolds as well as wound dressings, where bacterial infections in these medical devices can be serious or even fatal. However, such materials usually do not have inherent antimicrobial properties. They can be used as carriers for drug delivery or compounded with other antimicrobial materials to achieve antimicrobial effects. This review focuses on the antimicrobial behavior, preparation methods, and biocompatibility testing of biodegradable biocompatible synthetic polymers. Degradable biocompatible natural polymers with antimicrobial properties are also briefly described. Finally, the medical applications of these polymeric materials are presented.

• Item Type: Articles
• Additional Information: This work was supported by the National Natural Science Foundation of China (Grant no. 52003057), the Foshan Science and Technology Innovation Project (grant number FS0AA-KJ919- 4402-0145), MRC-UCL Therapeutic Acceleration Support (TAS) Fund (project no: 564022), NIHR UCLH BRC-UCL Therapeutic Acceleration Support (TAS) Fund (project no. 564021), and Wellcome Trust-Translational Partnership Award-UCL Regenerative Medicine TIN Pilot Dara Fund (Project no.: 569576), and Engineering and Physical Sciences Research Council via DTP CASE Programme (Grant no.: EP/T517793/1).
• Keywords: Natural polymers, medical applications, biocompatible, biodegradable, antibacterial, synthetic polymers.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Luo, Mr Jiajun

Creator Roles

Luo, J.: Investigation

• Authors: Deng, S., Chen, A., Chen, W., Lai, J., Pei, Y., Wen, J., Yang, C., Luo, J., Zhang, J., Lei, C., Varma, S. N., and Liu, C.
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: Polymers
• Publisher: MDPI
• ISSN: 2073-4360
• ISSN (Online): 2073-4360
• Published Online: 28 December 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Polymers 15(1): 120
• Publisher Policy: Reproduced under a Creative Commons License