Catto, J. W.F. et al. (2023) Diagnosis, treatment and survival from bladder, upper urinary tract, and urethral cancers: real-world findings from NHS England between 2013 and 2019. BJU International, 131(6), pp. 734-744. (doi: 10.1111/bju.15970) (PMID:36680312)
Text
289723.pdf - Published Version Available under License Creative Commons Attribution. 689kB | |
Text
289723Suppl.pdf - Supplemental Material 628kB |
Abstract
Objective: We report NHS England data for patients with bladder cancer (BC), upper tract urothelial (UTUC: renal pelvic and ureteric) and urethral cancers from 2013 to 2019. Materials and methods: Hospital episode statistics, waiting times and cancer registrations were extracted from NHS Digital. Results: Registrations included 128,823 individuals with BC, 16,018 with UTUC and 2,533 with urethral cancer. In 2019, 150,816 persons were living with a diagnosis of BC, of whom 113,067 (75.0%) were men, 85,117 (56.5%) aged over 75 yrs, and 95,553 (91.7%) Caucasian. Incidence rates were stable (32.7-34.3 for BC, 3.9-4.2 for UTUC and 0.6-0.7 for urethral cancer per 100,000 population). Most patients (52,097 (41.3% (40.7-42.0%)) were referred outside the two week wait pathway and 15,340 (12.2% (11.7-12.6%)) presented as emergencies. Surgery, radiotherapy, chemotherapy or multimodal treatment use varied with disease stage, patient factors and Cancer Alliance. Between 27-29% (6,616) of muscle-invasive BCs did not receive radical treatment. Survival rates reflected stage, grade, location and tumour histology. Overall survival rates did not improve over time (relative change: 0.97 (95%CI: 0.97-0.97) at 2 years) in contrast to other cancers. Conclusion: The diagnostic pathway for BC needs improvement. Increases in survival might be delivered through greater use in radical treatment. NHS Digital data offers a population-wide picture of this disease but does not allow individual outcomes to be matched with disease or patient features and key parameters can be missing or incomplete.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Jones, Professor Robert |
Authors: | Catto, J. W.F., Mandrik, O., Quayle, L. A., Hussain, S. A., McGrath, J., Cresswell, J., Birtle, A. J., Jones, R. J., Mariappan, P., Makaroff, L. E., Knight, A., Mostafid, H., Chilcott, J., Sasieni, P., and Cumberbatch, M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | BJU International |
Publisher: | Wiley |
ISSN: | 1464-4096 |
ISSN (Online): | 1464-410X |
Published Online: | 20 January 2023 |
Copyright Holders: | Copyright © 2023 The Authors |
First Published: | First published in BJU International 131(6):734-744 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record