Diagnosis, treatment and survival from bladder, upper urinary tract, and urethral cancers: real-world findings from NHS England between 2013 and 2019

Catto, J. W.F. et al. (2023) Diagnosis, treatment and survival from bladder, upper urinary tract, and urethral cancers: real-world findings from NHS England between 2013 and 2019. BJU International, 131(6), pp. 734-744. (doi: 10.1111/bju.15970) (PMID:36680312)

[img] Text
289723.pdf - Published Version
Available under License Creative Commons Attribution.

689kB
[img] Text
289723Suppl.pdf - Supplemental Material

628kB

Abstract

Objective: We report NHS England data for patients with bladder cancer (BC), upper tract urothelial (UTUC: renal pelvic and ureteric) and urethral cancers from 2013 to 2019. Materials and methods: Hospital episode statistics, waiting times and cancer registrations were extracted from NHS Digital. Results: Registrations included 128,823 individuals with BC, 16,018 with UTUC and 2,533 with urethral cancer. In 2019, 150,816 persons were living with a diagnosis of BC, of whom 113,067 (75.0%) were men, 85,117 (56.5%) aged over 75 yrs, and 95,553 (91.7%) Caucasian. Incidence rates were stable (32.7-34.3 for BC, 3.9-4.2 for UTUC and 0.6-0.7 for urethral cancer per 100,000 population). Most patients (52,097 (41.3% (40.7-42.0%)) were referred outside the two week wait pathway and 15,340 (12.2% (11.7-12.6%)) presented as emergencies. Surgery, radiotherapy, chemotherapy or multimodal treatment use varied with disease stage, patient factors and Cancer Alliance. Between 27-29% (6,616) of muscle-invasive BCs did not receive radical treatment. Survival rates reflected stage, grade, location and tumour histology. Overall survival rates did not improve over time (relative change: 0.97 (95%CI: 0.97-0.97) at 2 years) in contrast to other cancers. Conclusion: The diagnostic pathway for BC needs improvement. Increases in survival might be delivered through greater use in radical treatment. NHS Digital data offers a population-wide picture of this disease but does not allow individual outcomes to be matched with disease or patient features and key parameters can be missing or incomplete.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jones, Professor Robert
Authors: Catto, J. W.F., Mandrik, O., Quayle, L. A., Hussain, S. A., McGrath, J., Cresswell, J., Birtle, A. J., Jones, R. J., Mariappan, P., Makaroff, L. E., Knight, A., Mostafid, H., Chilcott, J., Sasieni, P., and Cumberbatch, M.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:BJU International
Publisher:Wiley
ISSN:1464-4096
ISSN (Online):1464-410X
Published Online:20 January 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in BJU International 131(6):734-744
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record