Glanemann, B. et al. (2023) Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia. Journal of Veterinary Internal Medicine, (doi: 10.1111/jvim.16613) (PMID:36609843) (PMCID:PMC9889603)
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Abstract
Background: After a strong epidemiological link to diet was established in an outbreak of pancytopenia in cats in spring 2021 in the United Kingdom, 3 dry diets were recalled. Concentrations of the hemato- and myelotoxic mycotoxins T-2, HT-2 and diacetoxyscirpenol (DAS) greater than the European Commission guidance for dry cat foods were detected in the recalled diets. Objectives: To describe clinical and clinicopathological findings in cats diagnosed with suspected diet induced pancytopenia. Animals: Fifty cats presenting with pancytopenia after exposure to a recalled diet. Methods: Multicenter retrospective case series study. Cats with known exposure to 1 of the recalled diets were included if presented with bi- or pancytopenia and underwent bone marrow examination. Results: Case fatality rate was 78%. Bone marrow aspirates and biopsy examination results were available in 23 cats; 19 cats had a bone marrow aspirate, and 8 cats had a biopsy core, available for examination. Bone marrow hypo to aplasia—often affecting all cell lines—was the main feature in all 31 available core specimens. A disproportionately pronounced effect on myeloid and megakaryocytic cells was observed in 19 cats. Myelofibrosis or bone marrow necrosis was not a feature. Conclusion and Clinical Importance: Mycotoxin induced pancytopenia should be considered as differential diagnosis in otherwise healthy cats presenting with bi- or pancytopenia and bone marrow hypo- to aplasia.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Lantzaki, Vasiliki |
Authors: | Glanemann, B., Humm, K., Abreu, M., Aspinall, S., Buckeridge, D., Carveth, H., Darcy, H., Florey, J., Frowde, P., Gajanayake, I., Green, K., Holmes, E., Hrovat, A., Jasensky, A.‐K., Jones, B. A., Lantzaki, V., Lo, E. J.Y., MacDonald, K., O'Brien, K., Suárez‐Bonnet, A., Van den Steen, N., Szladovits, B., Willems, A., and Wilson, H. |
College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Journal of Veterinary Internal Medicine |
Publisher: | Wiley |
ISSN: | 0891-6640 |
ISSN (Online): | 1939-1676 |
Published Online: | 07 January 2023 |
Copyright Holders: | Copyright © 2023 The Authors |
First Published: | First published in Journal of Veterinary Internal Medicine 2023 |
Publisher Policy: | Reproduced under a Creative Commons license |
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