Survey and evaluation of hypertension machine learning research

Du Toit, C. et al. (2023) Survey and evaluation of hypertension machine learning research. Journal of the American Heart Association, 12(9), e027896. (doi: 10.1161/JAHA.122.027896) (PMID:37119074) (PMCID:PMC10227215)

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Background: Machine learning (ML) is pervasive in all fields of research, from automating tasks to complex decision‐making. However, applications in different specialities are variable and generally limited. Like other conditions, the number of studies employing ML in hypertension research is growing rapidly. In this study, we aimed to survey hypertension research using ML, evaluate the reporting quality, and identify barriers to ML's potential to transform hypertension care. Methods and Results: The Harmonious Understanding of Machine Learning Analytics Network survey questionnaire was applied to 63 hypertension‐related ML research articles published between January 2019 and September 2021. The most common research topics were blood pressure prediction (38%), hypertension (22%), cardiovascular outcomes (6%), blood pressure variability (5%), treatment response (5%), and real‐time blood pressure estimation (5%). The reporting quality of the articles was variable. Only 46% of articles described the study population or derivation cohort. Most articles (81%) reported at least 1 performance measure, but only 40% presented any measures of calibration. Compliance with ethics, patient privacy, and data security regulations were mentioned in 30 (48%) of the articles. Only 14% used geographically or temporally distinct validation data sets. Algorithmic bias was not addressed in any of the articles, with only 6 of them acknowledging risk of bias. Conclusions: Recent ML research on hypertension is limited to exploratory research and has significant shortcomings in reporting quality, model validation, and algorithmic bias. Our analysis identifies areas for improvement that will help pave the way for the realization of the potential of ML in hypertension and facilitate its adoption.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Lip, Dr Stefanie and Padmanabhan, Professor Sandosh and Alsanosi, Dr Safaa and Aman, Ms Alisha and Rostron, Dr Maggie and Mccallum, Dr Linsay and Du Toit, Ms Clea and Sykes, Dr Robert and Nichol, Dr Sarah
Authors: Du Toit, C., Tran, T. Q. B., Deo, N., Aryal, S., Lip, S., Sykes, R., Manandhar, I., Sionakidis, A., Stevenson, L., Pattnaik, H., Alsanosi, S., Kassi, M., Le, N., Rostron, M., Nichol, S., Aman, A., Nawaz, F., Mehta, D., Tummala, R., McCallum, L., Reddy, S., Visweswaran, S., Kashyap, R., Joe, B., and Padmanabhan, S.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of the American Heart Association
Publisher:American Heart Association
ISSN (Online):2047-9980
Published Online:29 April 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in Journal of the American Heart Association 12(9): e027896
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303944BHF Centre of ExcellenceColin BerryBritish Heart Foundation (BHF)RE/18/6/34217CAMS - Cardiovascular Science
315953Mitigation of COVID-19 through cardiovascular pharmacotherapySandosh PadmanabhanBritish Heart Foundation (BHF)FS/MBPhD/22/28005CAMS - Cardiovascular Science