Modulating gut microbiota and metabolites with dietary fiber oat β-glucan interventions to improve growth performance and intestinal function in weaned rabbits

Ma, L. et al. (2022) Modulating gut microbiota and metabolites with dietary fiber oat β-glucan interventions to improve growth performance and intestinal function in weaned rabbits. Frontiers in Microbiology, 13, 1074036. (doi: 10.3389/fmicb.2022.1074036) (PMID:36590438) (PMCID:PMC9798315)

Abstract

The effect of oat β-glucan on intestinal function and growth performance of weaned rabbits were explored by multi-omics integrative analyses in the present study. New Zealand White rabbits fed oat β-glucan [200 mg/kg body weight (BW)] for 4 weeks, and serum markers, colon histological alterations, colonic microbiome, colonic metabolome, and serum metabolome were measured. The results revealed that oat β-glucan increased BW, average daily gain (ADG), average daily food intake (ADFI), and decreased serum tumor necrosis factor-α (TNF-α) interleukin-1β (IL-1β), and lipopolysaccharide (LPS) contents, but did not affect colonic microstructure. Microbiota community analysis showed oat β-glucan modulated gut microbial composition and structure, increased the abundances of beneficial bacteria Lactobacillus, Prevotellaceae_UCG-001, Pediococcus, Bacillus, etc. Oat β-glucan also increased intestinal propionic acid, valeric acid, and butyric acid concentrations, decreased lysine and aromatic amino acid (AAA) derivative contents. Serum metabolite analysis revealed that oat β-glucan altered host carbohydrate, lipid, and amino acid metabolism. These results suggested that oat β-glucan could inhibit systemic inflammation and protect intestinal function by regulating gut microbiota and related metabolites, which further helps to improve growth performance in weaned rabbits.

• Item Type: Articles
• Additional Information: This research was funded by the Open project of Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Chengdu University (grant no. 2022BC001), Chongqing Natural Science Foundation (grant no. 2022NSCQ-MSX5828), and the Sichuan Science and Technology Program (grant no. 2019YJ0671).
• Keywords: Microbiology, oat β-glucan, gut microbiota, metabolites, intestinal function, growth performance.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Huang, Yixin

Creator Roles

Huang, Y.: Writing – original draft, Writing – review and editing, Visualization

• Authors: Ma, L., Luo, Z., Huang, Y., Li, Y., Guan, J., Zhou, T., Du, Z., Yong, K., Yao, X., Shen, L., Yu, S., Zhong, Z., Hu, Y., Peng, G., Shi, X., and Cao, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Frontiers in Microbiology
• Publisher: Frontiers Media
• ISSN: 1664-302X
• ISSN (Online): 1664-302X
• Copyright Holders: Copyright © 2022 Ma, Luo, Huang, Li, Guan, Zhou, Du, Yong, Yao, Shen, Yu, Zhong, Hu, Peng, Shi and Cao
• First Published: First published in Frontiers in Microbiology 13: 1074036
• Publisher Policy: Reproduced under a Creative Commons License