A stabilized linear finite element method for anisotropic poroelastodynamics with application to cardiac perfusion

Thekkethil, N., Rossi, S., Gao, H. , Richardson, S. I. H., Griffith, B. E. and Luo, X. (2023) A stabilized linear finite element method for anisotropic poroelastodynamics with application to cardiac perfusion. Computer Methods in Applied Mechanics and Engineering, 405, 115877. (doi: 10.1016/j.cma.2022.115877)

[img] Text
288758.pdf - Published Version
Available under License Creative Commons Attribution.

7MB

Abstract

We propose a variational multiscale method stabilization of a linear finite element method for nonlinear poroelasticity. Our approach is suitable for the implicit time integration of poroelastic formulations in which the solid skeleton is anisotropic and incompressible. A detailed numerical methodology is presented for a monolithic formulation that includes both structural dynamics and Darcy flow. Our implementation of this methodology is verified using several hyperelastic and poroelastic benchmark cases, and excellent agreement is obtained with the literature. Grid convergence studies for both anisotropic hyperelastodynamics and poroelastodynamics demonstrate that the method is second-order accurate. The capabilities of our approach are demonstrated using a model of the left ventricle (LV) of the heart derived from human imaging data. Simulations using this model indicate that the anisotropicity of the myocardium has a substantial influence on the pore pressure. Furthermore, the temporal variations of the various components of the pore pressure (hydrostatic pressure and pressure resulting from changes in the volume of the pore fluid) are correlated with the variation of the added mass and dynamics of the LV, with maximum pore pressure being obtained at peak systole. The order of magnitude and the temporal variation of the pore pressure are in good agreement with the literature.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu and Thekkethil, Mr Namshad and Gao, Dr Hao and Richardson, Mr Scott and Griffith, Dr Boyce
Authors: Thekkethil, N., Rossi, S., Gao, H., Richardson, S. I. H., Griffith, B. E., and Luo, X.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Computer Methods in Applied Mechanics and Engineering
Publisher:Elsevier
ISSN:0045-7825
ISSN (Online):1879-2138
Published Online:07 January 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in Computer Methods in Applied Mechanics and Engineering 405: 115877
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303232EPSRC Centre for Multiscale soft tissue mechanics with MIT and POLIMI (SofTMech-MP)Xiaoyu LuoEngineering and Physical Sciences Research Council (EPSRC)EP/S030875/1M&S - Mathematics
303231A whole-heart model of multiscale soft tissue mechanics and fluid structureinteraction for clinical applications (Whole-Heart-FSI)Xiaoyu LuoEngineering and Physical Sciences Research Council (EPSRC)EP/S020950/1M&S - Mathematics
303798Growth and Remodelling in Neoanatal Porcine Heart-- Pushing Mathematics through ExperimentsXiaoyu LuoEngineering and Physical Sciences Research Council (EPSRC)EP/S014284/1M&S - Mathematics
309324Optimisation of prediction models for red blood cell demandAlice MillerEngineering and Physical Sciences Research Council (EPSRC)EP/R511705/1Computing Science