Mitochondrial function declines with age within individuals but is not linked to the pattern of growth or mortality risk in zebra finch

Salmon, P. , Dawson, N. J. , Millet, C., Selman, C. and Monaghan, P. (2023) Mitochondrial function declines with age within individuals but is not linked to the pattern of growth or mortality risk in zebra finch. Aging Cell, 22(6), e13822. (doi: 10.1111/acel.13822) (PMID:36938671) (PMCID:PMC10265141)

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Mitochondrial dysfunction is considered a highly conserved hallmark of ageing. However, most of the studies in both model and non-model organisms are cross-sectional in design; therefore, little is known, at the individual level, on how mitochondrial function changes with age, its link to early developmental conditions or its relationship with survival. Here we manipulated the postnatal growth in zebra finches (Taeniopygia guttata) via dietary modification that induced accelerated growth without changing adult body size. In the same individuals, we examined blood cells mitochondrial functioning (mainly erythrocytes) when they were young (ca. 36 weeks) and again in mid-aged (ca. 91 weeks) adulthood. Mitochondrial function was strongly influenced by age but not by postnatal growth conditions. Across all groups, within individual ROUTINE respiration, OXPHOS and OXPHOS coupling efficiency significantly declined with age, while LEAK respiration increased. However, we found no link between mitochondrial function and the probability of survival into relatively old age (ca. 4 years). Our results suggest that the association between accelerated growth and reduced longevity, evident in this as in other species, is not attributable to age-related changes in any of the measured mitochondrial function traits.

Item Type:Articles
Additional Information:Funding information: H2020 European Research Council, Grant/Award Number: 101020037; Hezkuntza, Hizkuntza Politika Eta Kultura Saila, Eusko Jaurlaritza, Grant/Award Number: POS2020-1-0007; Leverhulme Trust, Grant/ Award Number: RPG-2017-061.
Glasgow Author(s) Enlighten ID:Monaghan, Professor Pat and Selman, Professor Colin and Millet, Dr Caroline and Dawson, Dr Neal and Salmon, Dr Pablo
Authors: Salmon, P., Dawson, N. J., Millet, C., Selman, C., and Monaghan, P.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Aging Cell
ISSN (Online):1474-9726
Published Online:20 March 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in Aging Cell 22(6):e13822
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
174157Mechanisms underlying the growth-lifespan trade-offPatricia MonaghanLeverhulme Trust (LEVERHUL)RPG-2017-061Institute of Biodiversity, Animal Health and Comparative Medicine
312093InteragePatricia MonaghanEuropean Commission (EC)101020037Institute of Biodiversity, Animal Health and Comparative Medicine