Skou, S. T., Mair, F. S. , Fortin, M., Guthrie, B., Nunes, B. P., Miranda, J. J., Boyd, C. M., Pati, S., Mtenga, S. and Smith, S. M. (2022) Multimorbidity. Nature Reviews Disease Primers, 8, 48. (doi: 10.1038/s41572-022-00376-4) (PMID:35835758) (PMCID:PMC7613517)

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Multimorbidity (two or more coexisting conditions in an individual) is a growing global challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a decade earlier in socioeconomically deprived communities and is associated with premature death, poorer function and quality of life and increased health-care utilization. Mechanisms underlying the development of multimorbidity are complex, interrelated and multilevel, but are related to ageing and underlying biological mechanisms and broader determinants of health such as socioeconomic deprivation. Little is known about prevention of multimorbidity, but focusing on psychosocial and behavioural factors, particularly population level interventions and structural changes, is likely to be beneficial. Most clinical practice guidelines and health-care training and delivery focus on single diseases, leading to care that is sometimes inadequate and potentially harmful. Multimorbidity requires person-centred care, prioritizing what matters most to the individual and the individual’s carers, ensuring care that is effectively coordinated and minimally disruptive, and aligns with the patient’s values. Interventions are likely to be complex and multifaceted. Although an increasing number of studies have examined multimorbidity interventions, there is still limited evidence to support any approach. Greater investment in multimorbidity research and training along with reconfiguration of health care supporting the management of multimorbidity is urgently needed.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Mair, Professor Frances
Authors: Skou, S. T., Mair, F. S., Fortin, M., Guthrie, B., Nunes, B. P., Miranda, J. J., Boyd, C. M., Pati, S., Mtenga, S., and Smith, S. M.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care
Journal Name:Nature Reviews Disease Primers
Publisher:Nature Research
ISSN (Online):2056-676X

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
309238Multimorbidity in Africa - Increasing Understanding of the Patient Experience and Epidemiology (MAfricaEE)Frances MairMedical Research Council (MRC)MC_PC_MR/T037849/1HW - General Practice and Primary Care
309114Exploring the treatment burden and capacity for self care among patients with HIV/NCD Multimorbidity in South AfricaFrances MairMedical Research Council (MRC)MR/T03775X/1HW - General Practice and Primary Care