Moderate exercise protects against joint disease in a murine model of osteoarthritis

Huesa, C. et al. (2022) Moderate exercise protects against joint disease in a murine model of osteoarthritis. Frontiers in Physiology, 13, 1065278. (doi: 10.3389/fphys.2022.1065278) (PMID:36545287) (PMCID:PMC9760924)

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Exercise is recommended as a non-pharmacological therapy for osteoarthritis (OA). Various exercise regimes, with differing intensities and duration, have been used in a range of OA rodent models. These studies show gentle or moderate exercise reduces the severity of OA parameters while high intensity load bearing exercise is detrimental. However, these studies were largely conducted in rats or in mouse models induced by severe injury, age or obesity, whilst destabilization of the medial meniscus (DMM) in mice has become a widely accepted model due to its lower variability, moderate progression and timescale. The present study was undertaken to provide insight into the effect of moderate exercise on early joint pathology in the DMM mouse model. Exercise was induced a week after induction by forced wheel walking for three or 7 weeks. Joints were analyzed by microcomputed tomography and histology. Assessment of skeletal parameters revealed that exercise offered protection against cartilage damage after 7 weeks of exercise, and a temporary protection against osteosclerosis was displayed after 3 weeks of exercise. Furthermore, exercise modified the metaphyseal trabecular microarchitecture of the osteoarthritic leg in both time points examined. Collectively, our findings corroborate previous studies showing that exercise has an important effect on bone in OA, which subsequently, at 8 weeks post-induction, translates into less cartilage damage. Thus, providing an exercise protocol in a surgical mouse model of OA, which can be used in the future to further dissect the mechanisms by which moderate exercise ameliorates OA.

Item Type:Articles
Additional Information:This work (CH and LD) was supported by an Arthritis Research United Kingdom programme grant (20199) and Versus Arthritis Early Career Fellowship (CH, 22483). MF, AO, and KM were supported by University of the West of Scotland studentships. SM was supported by a Medical Research Scotland studentship.
Keywords:Exercise, osteoarthritis, bone, cartilage, destabilisation of medial meniscus model, subchondral bone.
Glasgow Author(s) Enlighten ID:McGrath, Sarah and Ferrell, Professor William and Huesa, Dr Carmen and Goodyear, Professor Carl
Creator Roles:
Huesa, C.Conceptualization, Methodology, Formal analysis, Investigation, Data curation, Writing – original draft, Visualization, Supervision, Project administration, Funding acquisition
McGrath, S.Investigation
Ferrell, W. R.Conceptualization, Methodology, Investigation, Writing – original draft, Supervision, Project administration, Funding acquisition
Goodyear, C. S.Conceptualization, Writing – original draft, Supervision, Project administration, Funding acquisition
Authors: Huesa, C., Dunning, L., MacDougall, K., Fegen, M., Ortiz, A., McCulloch, K., McGrath, S., Litherland, G. J., Crilly, A., Van ‘T Hof, R. J., Ferrell, W. R., Goodyear, C. S., and Lockhart, J. C.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Research Centre:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
Journal Name:Frontiers in Physiology
Publisher:Frontiers Media
ISSN (Online):1664-042X
Copyright Holders:Copyright © 2022 Huesa, Dunning, MacDougall, Fegen, Ortiz, McCulloch, McGrath, Litherland, Crilly, Van ‘T Hof, Ferrell, Goodyear and Lockhart
First Published:First published in Frontiers in Physiology 13: 1065278
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190582Lessening the burden of osteoarthritis: elucidating the pathogenic role of the PAR-2 Pathway.Carl GoodyearVersus Arthritis (ARTRESUK)20199III - Immunology
308503Targeting osteoarthritic pain through Proteinase Activated Receptor 2 (PAR2)Carl GoodyearVersus Arthritis (ARTRESUK)22483III - Immunology