Anticholinergic deprescribing interventions for reducing risk of cognitive decline or dementia in older adults with and without prior cognitive impairment

Taylor-Rowan, M. , Alharthi, A. A., Noel-Storr, A. H., Myint, P. K., Stewart, C., McCleery, J. and Quinn, T. J. (2022) Anticholinergic deprescribing interventions for reducing risk of cognitive decline or dementia in older adults with and without prior cognitive impairment. Cochrane Database of Systematic Reviews, 2022(12), CD015405. (doi: 10.1002/14651858.cd015405) (PMCID:PMC9730444)

Abstract

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective: To assess the efficacy and safety of anticholinergic medication reduction interventions to improve cognitive outcomes in both cognitively healthy older adults and older adults with pre‐existing cognitive issues. Secondary objectives: To compare the effectiveness of different types of reduction interventions (e.g. pharmacist‐led versus GP‐led; educational versus audit and feedback) in reducing overall anticholinergic burden. To establish optimal duration of anticholinergic reduction interventions; sustainability, and lessons learned for upscaling To compare results according to differing anticholinergic scales used in medication reduction intervention trials. To assess the efficacy of anticholinergic medication reduction interventions to improve other clinical outcomes, including mortality, quality of life, clinical global impression, physical function, institutionalisation, falls, cardiovascular diseases, and neurobehavioral outcomes in people with pre‐existing cognitive impairment.

• Item Type: Articles
• Additional Information: This protocol was supported by the National Institute for Health and Care Research (NIHR), via Cochrane Infrastructure funding to the Cochrane Dementia and Cognitive Improvement group.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Quinn, Professor Terry and Taylor-Rowan, Dr Martin
• Authors: Taylor-Rowan, M., Alharthi, A. A., Noel-Storr, A. H., Myint, P. K., Stewart, C., McCleery, J., and Quinn, T. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care
• Journal Name: Cochrane Database of Systematic Reviews
• Publisher: Cochrane Collaboration
• ISSN: 1469-493X
• ISSN (Online): 1469-493X
• Copyright Holders: Copyright © 2022 The Cochrane Collaboration
• First Published: First published in Cochrane Database of Systematic Reviews 2022(12):CD015405
• Publisher Policy: Reproduced in accordance with the publisher copyright policy