Topographic organization of eye-position dependent gain fields in human visual cortex

Fabius, J. H., Moravkova, K. and Fracasso, A. (2022) Topographic organization of eye-position dependent gain fields in human visual cortex. Nature Communications, 13, 7925. (doi: 10.1038/s41467-022-35488-8) (PMID:36564372) (PMCID:PMC9789150)

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The ability to move has introduced animals with the problem of sensory ambiguity: the position of an external stimulus could change over time because the stimulus moved, or because the animal moved its receptors. This ambiguity can be resolved with a change in neural response gain as a function of receptor orientation. Here, we developed an encoding model to capture gain modulation of visual responses in high field (7 T) fMRI data. We characterized population eye-position dependent gain fields (pEGF). The information contained in the pEGFs allowed us to reconstruct eye positions over time across the visual hierarchy. We discovered a systematic distribution of pEGF centers: pEGF centers shift from contra- to ipsilateral following pRF eccentricity. Such a topographical organization suggests that signals beyond pure retinotopy are accessible early in the visual hierarchy, providing the potential to solve sensory ambiguity and optimize sensory processing information for functionally relevant behavior.

Item Type:Articles
Additional Information:A.F. is supported by a grant from the Biotechnology and Biology research council (BBSRC, grant number: BB/S006605/1) and the Bial Foundation, Bial Foundation Grants Programme Grant ID: A-29315, number: 203/2020, grant edition: G-15516.
Glasgow Author(s) Enlighten ID:Fracasso, Dr Alessio and Moravkova, Katarina and Fabius, Mr Jasper
Authors: Fabius, J. H., Moravkova, K., and Fracasso, A.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Nature Communications
Publisher:Nature Research
ISSN (Online):2041-1723
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Nature Communications 13: 7925
Publisher Policy:Reproduced under a Creative Commons License
Data DOI:10.17605/OSF.IO/GTD5R

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303685Stable perception of external stimuli over time: oculo-motor and visual processing mechanismsAlessio FracassoBiotechnology and Biological Sciences Research Council (BBSRC)BB/S006605/1Centre for Cognitive Neuroimaging