An endogenous lentivirus in the germline of a rodent

Kambol, R., Gatseva, A. and Gifford, R. J. (2022) An endogenous lentivirus in the germline of a rodent. Retrovirology, 19, 30. (doi: 10.1186/s12977-022-00615-2) (PMID:36539757) (PMCID:PMC9768972)

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Lentiviruses (genus Lentivirus) are complex retroviruses that infect a broad range of mammals, including humans. Unlike many other retrovirus genera, lentiviruses have only rarely been incorporated into the mammalian germline. However, a small number of endogenous retrovirus (ERV) lineages have been identified, and these rare genomic “fossils” can provide crucial insights into the long-term history of lentivirus evolution. Here, we describe a previously unreported endogenous lentivirus lineage in the genome of the South African springhare (Pedetes capensis), demonstrating that the host range of lentiviruses has historically extended to rodents (order Rodentia). Furthermore, through comparative and phylogenetic analysis of lentivirus and ERV genomes, considering the biogeographic and ecological characteristics of host species, we reveal broader insights into the long-term evolutionary history of the genus.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Gifford, Dr Robert and Gatseva, Miss Anna
Authors: Kambol, R., Gatseva, A., and Gifford, R. J.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Retrovirology
Publisher:BioMed Central
ISSN (Online):1742-4690
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Retrovirology 19: 30
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172630015Cross-Cutting Programme - Viral Genomics and Bioinformatics (Programme 9)Andrew DavisonMedical Research Council (MRC)MC_UU_12014/12III - Centre for Virus Research