Kambol, R., Gatseva, A. and Gifford, R. J. (2022) An endogenous lentivirus in the germline of a rodent. Retrovirology, 19, 30. (doi: 10.1186/s12977-022-00615-2) (PMID:36539757) (PMCID:PMC9768972)
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Abstract
Lentiviruses (genus Lentivirus) are complex retroviruses that infect a broad range of mammals, including humans. Unlike many other retrovirus genera, lentiviruses have only rarely been incorporated into the mammalian germline. However, a small number of endogenous retrovirus (ERV) lineages have been identified, and these rare genomic “fossils” can provide crucial insights into the long-term history of lentivirus evolution. Here, we describe a previously unreported endogenous lentivirus lineage in the genome of the South African springhare (Pedetes capensis), demonstrating that the host range of lentiviruses has historically extended to rodents (order Rodentia). Furthermore, through comparative and phylogenetic analysis of lentivirus and ERV genomes, considering the biogeographic and ecological characteristics of host species, we reveal broader insights into the long-term evolutionary history of the genus.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gifford, Dr Robert and Gatseva, Dr Anna |
| Authors: | Kambol, R., Gatseva, A., and Gifford, R. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Retrovirology |
| Publisher: | BioMed Central |
| ISSN: | 1742-4690 |
| ISSN (Online): | 1742-4690 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in Retrovirology 19: 30 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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