Oscillations support short latency co-firing of neurons during human episodic memory formation

Roux, F. et al. (2022) Oscillations support short latency co-firing of neurons during human episodic memory formation. eLife, 11, e78109. (doi: 10.7554/elife.78109) (PMID:36448671) (PMCID:PMC9731574)

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Theta and gamma oscillations in the medial temporal lobe are suggested to play a critical role for human memory formation via establishing synchrony in neural assemblies. Arguably, such synchrony facilitates efficient information transfer between neurons and enhances synaptic plasticity, both of which benefit episodic memory formation. However, to date little evidence exists from humans that would provide direct evidence for such a specific role of theta and gamma oscillations for episodic memory formation. Here, we investigate how oscillations shape the temporal structure of neural firing during memory formation in the medial temporal lobe. We measured neural firing and local field potentials in human epilepsy patients via micro-wire electrode recordings to analyze whether brain oscillations are related to co-incidences of firing between neurons during successful and unsuccessful encoding of episodic memories. The results show that phase-coupling of neurons to faster theta and gamma oscillations correlates with co-firing at short latencies (~20–30 ms) and occurs during successful memory formation. Phase-coupling at slower oscillations in these same frequency bands, in contrast, correlates with longer co-firing latencies and occurs during memory failure. Thus, our findings suggest that neural oscillations play a role for the synchronization of neural firing in the medial temporal lobe during the encoding of episodic memories.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Hanslmayr, Professor Simon and Kolibius, Luca and ter Wal, Ms Marije and Kreiselmeyer, Dr Gernot and Wimber, Professor Maria and Roux, Dr Frederic
Creator Roles:
Roux, F.Conceptualization, Data curation, Software, Formal analysis, Investigation, Methodology, Writing – original draft, Project administration, Writing – review and editing
Kreiselmeyer, G.Resources, Methodology, Project administration
ter Wal, M. J.Resources, Software, Methodology, Writing – review and editing
Kolibius, L.Resources, Investigation, Writing – review and editing
Wimber, M.Data curation, Project administration, Writing – review and editing
Hanslmayr, S.Conceptualization, Data curation, Software, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing – original draft, Project administration, Writing – review and editing
Authors: Roux, F., Parish, G., Chelvarajah, R., Rollings, D. T., Sawlani, V., Hamer, H., Gollwitzer, S., Kreiselmeyer, G., ter Wal, M. J., Kolibius, L., Staresina, B. P., Wimber, M., Self, M. W., and Hanslmayr, S.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:eLife
Publisher:eLife Sciences Publications
ISSN (Online):2050-084X
Copyright Holders:Copyright © 2022 Roux et al.
First Published:First published in eLife 11: e78109
Publisher Policy:Reproduced under a Creative Commons License
Data DOI:10.17605/OSF.IO/FNGZ8

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
313261Neural oscillations - a code for memorySimon HanslmayrEuropean Commission (EC)N/ACentre for Cognitive Neuroimaging
314597TIME - GLUING CROSS-MODAL MEMORIES VIA SYNCHRONISATIONSimon HanslmayrEconomic and Social Research Council (ESRC)ES/R010072/2Centre for Cognitive Neuroimaging