Kolch, W., Calder, M. and Gilbert, D. (2005) When kinases meet mathematics: the systems biology of MAPK signalling. FEBS Letters, 579(8), pp. 1891-1895. (doi: 10.1016/j.febslet.2005.02.002)
|
Text
kinmetmath.pdf 301kB |
Publisher's URL: http://dx.doi.org/10.1016/j.febslet.2005.02.002
Abstract
The mitogen activated protein kinase/extracellular signal regulated kinase pathway regulates fundamental cellular function such as cell proliferation, survival, differentiation and motility, raising the question how these diverse functions are specified and coordinated. They are encoded through the activation kinetics of the pathway, a multitude of feedback loops, scaffold proteins, subcellular compartmentalisation, and crosstalk with other pathways. These regulatory motifs alone or in combination can generate a multitude of complex behaviour. Systems biology tries to decode this complexity through mathematical modelling and prediction in order to gain a deeper insight into the inner works of signalling networks.
Item Type: | Articles |
---|---|
Keywords: | Mitogen activated protein kinase/extracellular signal regulated kinase, Signalling networks, Systems biology, Computational modelling |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Calder, Professor Muffy |
Authors: | Kolch, W., Calder, M., and Gilbert, D. |
Subjects: | Q Science > QA Mathematics |
College/School: | College of Science and Engineering > School of Computing Science |
Journal Name: | FEBS Letters |
Publisher: | Elsevier |
ISSN: | 0014-5793 |
Copyright Holders: | Copyright © 2005 Elsevier |
First Published: | First published in FEBS Letters 579(8):1891-1895 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record