Concurrent contextual and time-distant mnemonic information co-exist as feedback in the human visual cortex

Ortiz-Tudela, J., Bergmann, J., Bennett, M., Ehrlich, I., Muckli, L. and Shing, Y.-L. (2023) Concurrent contextual and time-distant mnemonic information co-exist as feedback in the human visual cortex. NeuroImage, 265, 119778. (doi: 10.1016/j.neuroimage.2022.119778) (PMID:36462731) (PMCID:PMC9878579)

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Efficient processing of the visual environment necessitates the integration of incoming sensory evidence with concurrent contextual inputs and mnemonic content from our past experiences. To examine how this integration takes place in the brain, we isolated different types of feedback signals from the neural patterns of non-stimulated areas of the early visual cortex in humans (i.e., V1 and V2). Using multivariate pattern analysis, we showed that both contextual and time-distant information, coexist in V1 and V2 as feedback signals. In addition, we found that the extent to which mnemonic information is reinstated in V1 and V2 depends on whether the information is retrieved episodically or semantically. Critically, this reinstatement was independent on the retrieval route in the object-selective cortex. These results demonstrate that our early visual processing contains not just direct and indirect information from the visual surrounding, but also memory-based predictions.

Item Type:Articles
Additional Information:Funding sources: European Research Council Starting grant ERC-2018-StG-PIVOTAL-758898 (YLS). Jacobs Foundation Research Fellowship JRF 2018–2020 (YLS). German Research Foundation Project ID 327654276, SFB 1315, “Mechanisms and Disturbances in Memory Consolidation: From Synapses to Systems” (YLS). Goethe Research Academy for Early Career Researchers - Fokus A/B program (JO). Hessian Ministry of Higher Education, Science, Research and Art, “The Adaptive Mind” (YLS).
Glasgow Author(s) Enlighten ID:Bennett, Mr Matthew and Ortiz-Tudela, Dr Javier and Bergmann, Dr Johanna and Muckli, Professor Lars
Creator Roles:
Ortiz-Tudela, J.Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft, Writing – review and editing
Bergmann, J.Methodology, Writing – review and editing
Bennett, M.Methodology, Writing – review and editing
Muckli, L.Methodology, Supervision, Writing – review and editing
Authors: Ortiz-Tudela, J., Bergmann, J., Bennett, M., Ehrlich, I., Muckli, L., and Shing, Y.-L.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:NeuroImage
ISSN (Online):1095-9572
Published Online:30 November 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in NeuroImage 265: 119778
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
304228PIVOTALLars MuckliEuropean Commission (EC)758898Centre for Cognitive Neuroimaging