Targeted therapies for microvascular disease

Bland, A., Chuah, E., Meere, W. and Ford, T. J. (2023) Targeted therapies for microvascular disease. Interventional Cardiology Clinics, 12(1), pp. 131-139. (doi: 10.1016/j.iccl.2022.09.011) (PMID:36372457)

Abstract

Coronary microvascular dysfunction (CMD) is a common cause of ischemia but no obstructive coronary artery disease that results in an inability of the coronary microvasculature to meet myocardial oxygen demand. CMD is challenging to diagnose and manage due to a lack of mechanistic research and targeted therapy. Recent evidence suggests we can improved patient outcomes by stratifying antianginal therapies according to the diagnosis revealed by invasive assessment of the coronary microcirculation. This review article appraises the evidence for management of CMD, which includes treatment of cardiovascular risk, antianginal therapy and therapy for atherosclerosis.

• Item Type: Articles
• Keywords: Myocardial Ischemia - drug therapy, coronary artery disease - diagnosis, angina, CMD, microcirculation, ischemia, INOCA, coronary circulation, management, humans.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ford, Thomas
• Authors: Bland, A., Chuah, E., Meere, W., and Ford, T. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Interventional Cardiology Clinics
• Publisher: Elsevier
• ISSN: 2211-7458
• ISSN (Online): 2211-7466
• Published Online: 10 November 2022
• Copyright Holders: Copyright © 2022 Elsevier
• First Published: First published in Interventional Cardiology Clinics 12(1):131-139
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher