A rapid review of patient-reported outcomes investigated in the context of advanced renal cell cancer or advanced hepatocellular cancer

Diez de los Rios de la Serna, C., Kotronoulas, G. , Drury, A., Oldenmenger, W. and Kelly, D. (2023) A rapid review of patient-reported outcomes investigated in the context of advanced renal cell cancer or advanced hepatocellular cancer. European Journal of Oncology Nursing, 63, 102241. (doi: 10.1016/j.ejon.2022.102241)

Abstract

Background: Patient-reported outcomes (PROs) are key indicators of health status and functioning, coming directly from the patient. Comprehensive monitoring of PROs enables implementation of person-centred care. Currently, the PROs that patients with advanced renal cell carcinoma (RCC) or hepatocellular carcinoma (HCC) consider of greatest importance remains unknown. Methods: A rapid literature review was carried out to identify PROs commonly reported in clinical studies of patients with advanced RCC/HCC. We searched MEDLINE, CINAHL & PsycInfo for relevant peer-reviewed publications in the period from 2000 to 2021. Pre-specified selection criteria were applied to all retrieved records. Findings were integrated into a narrative synthesis. Results: Eighty-one studies met our selection criteria and were retained. Most research was on advanced RCC (n = 64, 79%); 46 studies (57%) were drug trials. No qualitative research on PROs was found. Only twenty-six studies (32%) employed PROs as their primary endpoint. Most PROs concerned physical symptoms (45% RCC, 54% HCC) and emotional wellbeing (19% RCC, 16% HCC). The most common outcome measured was quality of life (65% of the total), followed by fatigue (62%) and pain (54%). Whether selection of these PROs was patient-driven was not reported. Conclusions: A wide range of PROs were assessed. Deficits in PROs often cause patients to seek out help; however, which PROs matter the most to people with advanced RCC/HCC must be further clarified. Targeting, monitoring, and responding to the ‘right’ PROs can enhance provision of person-centred care in advanced RCC/HCC and augment the clinical efficacy of established and emerging targeted therapies.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kotronoulas, Dr Greg and Diez de los Rios de la Serna, Mrs Celia
• Authors: Diez de los Rios de la Serna, C., Kotronoulas, G., Drury, A., Oldenmenger, W., and Kelly, D.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Nursing and Health Care
• Journal Name: European Journal of Oncology Nursing
• Publisher: Elsevier
• ISSN: 1462-3889
• ISSN (Online): 1532-2122
• Published Online: 16 November 2022
• Copyright Holders: Copyright © 2022 Elsevier Ltd.
• First Published: First published in European Journal of Oncology Nursing 63:102241
• Publisher Policy: Reproduced in accordance with the publisher copyright policy