Surgical or percutaneous coronary revascularization for heart failure: an in silico model using routinely collected health data to emulate a clinical trial

Pathak, S., Lai, F. Y., Miksza, J., Petrie, M. C. , Roman, M., Murray, S., Dearling, J., Perera, D. and Murphy, G. J. (2023) Surgical or percutaneous coronary revascularization for heart failure: an in silico model using routinely collected health data to emulate a clinical trial. European Heart Journal, 44(5), pp. 351-364. (doi: 10.1093/eurheartj/ehac670) (PMID:36350978) (PMCID:PMC9890210)

Abstract

Background: The choice of revascularization with coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) in people with ischaemic left ventricular dysfunction is not guided by high-quality evidence. Methods: A trial of CABG versus PCI in people with heart failure was modelled in-silico using routinely collected healthcare data. The in-silico trial cohort was selected by matching the target trial cohort, identified from Hospital Episode Statistics in England, with individual patient data from the STICH trial. Allocation to CABG versus complex PCI demonstrated random variation across administrative regions in England and was a valid statistical instrument. The primary outcome was 5-year all-cause mortality or cardiovascular hospitalization. Instrumental variable analysis (IVA) was used for the primary analysis. Results: were expressed as average treatment effects (ATEs) with 95% confidence intervals (CI). Results The target population included 13,519 heart failure patients undergoing CABG or complex PCI between April 2009 and March 2015. After matching, the emulated trial cohort included 2046 patients. The unadjusted primary outcome rate was 51.1% in the CABG group and 70.0% in the PCI group. IVA of the emulated cohort showed that CABG was associated with a lower risk of the primary outcome (ATE -16.2%, 95% CI -20.6% to -11.8%), with comparable estimates in the unmatched target population (ATE -15.5%, 95% CI -17.5% to -13.5%). Conclusions: In people with heart failure, in-silico modelling suggests that CABG is associated with fewer deaths or cardiovascular hospitalizations at 5 years versus complex PCI. A pragmatic clinical trial is needed to test this hypothesis and this trial would be feasible.

• Item Type: Articles
• Additional Information: Funding: Leicester NIHR Biomedical Research Centre, British Heart Foundation CH/12/1/29419, AA18/3/34220.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Petrie, Professor Mark
• Authors: Pathak, S., Lai, F. Y., Miksza, J., Petrie, M. C., Roman, M., Murray, S., Dearling, J., Perera, D., and Murphy, G. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: European Heart Journal
• Publisher: Oxford University Press
• ISSN: 0195-668X
• ISSN (Online): 1522-9645
• Published Online: 25 November 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in European Heart Journal 44(5):351-364
• Publisher Policy: Reproduced under a Creative Commons License