Fragoulis, G. E. et al. (2023) 2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases. Annals of the Rheumatic Diseases, 82(6), pp. 742-753. (doi: 10.1136/ard-2022-223335) (PMID:36328476)
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Abstract
To develop EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in patients with autoimmune inflammatory rheumatic diseases (AIIRD). An international Task Force (TF) (22 members/15 countries) formulated recommendations, supported by systematic literature review findings. Level of evidence and grade of recommendation were assigned for each recommendation. Level of agreement was provided anonymously by each TF member. Four overarching principles (OAP) and eight recommendations were developed. The OAPs highlight the need for infections to be discussed with patients and with other medical specialties, in accordance with national regulations. In addition to biologic/targeted synthetic disease-modifying antirheumatic drugs (DMARDs) for which screening for latent tuberculosis (TB) should be performed, screening could be considered also before conventional synthetic DMARDs, glucocorticoids and immunosuppressants. Interferon gamma release assay should be preferred over tuberculin skin test, where available. Hepatitis B (HBV) antiviral treatment should be guided by HBV status defined prior to starting antirheumatic drugs. All patients positive for hepatitis-C-RNA should be referred for antiviral treatment. Also, patients who are non-immune to varicella zoster virus should be informed about the availability of postexposure prophylaxis should they have contact with this pathogen. Prophylaxis against seems to be beneficial in patients treated with daily doses >15-30 mg of prednisolone or equivalent for >2-4 weeks. These recommendations provide guidance on the screening and prevention of chronic and opportunistic infections. Their adoption in clinical practice is recommended to standardise and optimise care to reduce the burden of opportunistic infections in people living with AIIRD.
| Item Type: | Articles |
|---|---|
| Additional Information: | The systematic literature review was funded as part of the EULAR Quality of Care Committee (Cl118) project for the 2022 EULAR recommendations on the screening and prophylaxis of chronic and opportunistic infections. KLH is also supported by the NIHR Manchester Biomedical Research Centre. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Fragkoulis, Dr Georgios |
| Authors: | Fragoulis, G. E., Nikiphorou, E., Dey, M., Zhao, S. S., Courvoisier, D. S., Arnaud, L., Atzeni, F., Behrens, G. M.N., Bijlsma, J. W.J., Böhm, P., Constantinou, C. A., Garcia-Diaz, S., Kapetanovic, M. C., Lauper, K., Luís, M., Morel, J., Nagy, G., Poleverino, E., van Rompay, J., Sebastiani, M., Strangfeld, A., de Thurah, A., Galloway, J., and Hyrich, K. L. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Annals of the Rheumatic Diseases |
| Publisher: | BMJ Publishing Group |
| ISSN: | 0003-4967 |
| ISSN (Online): | 1468-2060 |
| Published Online: | 03 November 2022 |
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