Lactate dehydrogenase: relationship with the diagnostic GLIM criterion for cachexia in patients with advanced cancer

McGovern, J., Dolan, R. D. , Simmons, C. P.L., Daly, L. E., Ryan, A. M., Power, D. G., Maguire, D., Fallon, M. T., Laird, B. J. and McMillan, D. C. (2023) Lactate dehydrogenase: relationship with the diagnostic GLIM criterion for cachexia in patients with advanced cancer. British Journal of Cancer, 128(5), pp. 760-765. (doi: 10.1038/s41416-022-02099-5) (PMID:36517550) (PMCID:PMC9977728)

Abstract

Background: Although suggestive of dysregulated metabolism, the relationship between serum LDH level, phenotypic/aetiologic diagnostic Global Leadership Initiative on Malnutrition (GLIM) criteria and survival in patients with advanced cancer has yet to examined. Methods: Prospectively collected data from patients with advanced cancer, undergoing anti-cancer therapy with palliative intent, across nine sites in the UK and Ireland between 2011–2016, was retrospectively analysed. LDH values were grouped as <250/250–500/>500 Units/L. Relationships were examined using χ2 test for linear-by-linear association and binary logistics regression analysis. Results: A total of 436 patients met the inclusion criteria. 46% (n = 200) were male and 59% (n = 259) were ≥65 years of age. The median serum LDH was 394 Units/L and 33.5% (n = 146) had an LDH > 500 Units/L. LDH was significantly associated with ECOG-PS (p < 0.001), NLR (p < 0.05), mGPS (p < 0.05) and 3-month survival (p < 0.001). LDH was significantly associated with 3-month survival independent of weight loss (p < 0.01), BMI (p < 0.05), skeletal muscle mass (p < 0.01), metastatic disease (p < 0.05), NLR (p < 0.05) and mGPS (p < 0.01). Discussion: LDH was associated with performance status, systemic inflammation and survival in patients with advanced cancer. LDH measurement may be considered as an aetiologic criteria and become a potential therapeutic target in the treatment of cancer cachexia.

• Item Type: Articles
• Additional Information: This research was funded by Medical Research Scotland (487FRG), the University of Glasgow, the University of Edinburgh and University College Cork.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Maguire, Donogh and Ryan, Dr Aoife and Dolan, Dr Ross and McMillan, Professor Donald and Laird, Dr Barry and McGovern, Mr Josh
• Authors: McGovern, J., Dolan, R. D., Simmons, C. P.L., Daly, L. E., Ryan, A. M., Power, D. G., Maguire, D., Fallon, M. T., Laird, B. J., and McMillan, D. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: British Journal of Cancer
• Publisher: Springer Nature
• ISSN: 0007-0920
• ISSN (Online): 1532-1827
• Published Online: 14 December 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in British Journal of Cancer 128(5): 760-765
• Publisher Policy: Reproduced under a Creative Commons License