Sunzini, F., Schrepf, A., Clauw, D. J. and Basu, N. (2023) The biology of pain: through the rheumatology lens. Arthritis and Rheumatology, 75(5), pp. 650-660. (doi: 10.1002/art.42429) (PMID:36599071)
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Abstract
Chronic pain is a major socio-economic burden globally. The most frequent origin for chronic pain is musculoskeletal. In inflammatory musculoskeletal diseases, such as rheumatoid arthritis (RA), chronic pain is a primary determinant of deleterious quality of life. The pivotal role of peripheral inflammation in the initiation and perpetuation of nociceptive pain is well-established among these patients. However, the persistence of pain, even after the apparent resolution of peripheral inflammation, alludes to the co-existence of different pain states. Recent advances in neurobiological knowledge have highlighted the importance of nociplastic pain mechanisms. In this review we aim to explore the biology of pain with a particular focus on nociplastic pain and RA.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Basu, Professor Neil and Sunzini, Miss Flavia and Schrepf, Mr Andrew |
Authors: | Sunzini, F., Schrepf, A., Clauw, D. J., and Basu, N. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
Journal Name: | Arthritis and Rheumatology |
Publisher: | Wiley |
ISSN: | 2326-5191 |
ISSN (Online): | 2326-5205 |
Published Online: | 04 January 2023 |
Copyright Holders: | Copyright © 2023 The Authors |
First Published: | First published in Arthritis and Rheumatology 75(5): 650-660 |
Publisher Policy: | Reproduced under a Creative Commons License |
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