The biology of pain: through the rheumatology lens

Sunzini, F., Schrepf, A., Clauw, D. J. and Basu, N. (2023) The biology of pain: through the rheumatology lens. Arthritis and Rheumatology, 75(5), pp. 650-660. (doi: 10.1002/art.42429) (PMID:36599071)

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Abstract

Chronic pain is a major socio-economic burden globally. The most frequent origin for chronic pain is musculoskeletal. In inflammatory musculoskeletal diseases, such as rheumatoid arthritis (RA), chronic pain is a primary determinant of deleterious quality of life. The pivotal role of peripheral inflammation in the initiation and perpetuation of nociceptive pain is well-established among these patients. However, the persistence of pain, even after the apparent resolution of peripheral inflammation, alludes to the co-existence of different pain states. Recent advances in neurobiological knowledge have highlighted the importance of nociplastic pain mechanisms. In this review we aim to explore the biology of pain with a particular focus on nociplastic pain and RA.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Basu, Professor Neil and Sunzini, Miss Flavia and Schrepf, Mr Andrew
Authors: Sunzini, F., Schrepf, A., Clauw, D. J., and Basu, N.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Research Centre:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
Journal Name:Arthritis and Rheumatology
Publisher:Wiley
ISSN:2326-5191
ISSN (Online):2326-5205
Published Online:04 January 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in Arthritis and Rheumatology 75(5): 650-660
Publisher Policy:Reproduced under a Creative Commons License

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