Association of extent of resection and functional outcomes in diffuse low-grade glioma: systematic review & meta-analysis.

Elsheikh, M. , Bridgman, E., Lavrador, J. P., Lammy, S. and Poon, M. T. C. (2022) Association of extent of resection and functional outcomes in diffuse low-grade glioma: systematic review & meta-analysis. Journal of Neuro-Oncology, 160(3), pp. 717-724. (doi: 10.1007/s11060-022-04192-4) (PMID:36404358)

Abstract

Background: Surgical resection offers survival benefits in patients with diffuse low-grade glioma (DLGG) but its association with functional outcomes is uncertain. This systematic review assessed functional outcomes associated with extent of resection (EoR) in adults with DLGG. Methods: We searched Medline, Embase and CENTRAL on the 19th of February 2021 for observational studies reporting functional outcomes after surgical resection for patients aged ≥ 18 years with a new diagnosis of supratentorial DLGG according to any World Health Organization classification of primary brain tumors. The Newcastle–Ottawa Scale (NOS) informed our risk of bias assessments. The proportion of patients returning to work within 12 months entered a random-effects meta-analysis. PROSPERO registration number CRD42021238387. Results: There were seven eligible moderate to high-quality (NOS > 6) observational studies identified from 1,183 records involving 234 patients with DLGG. Functional outcomes reported included neurocognition (n = 2 studies), performance status (n = 3), quality of life (QoL) (n = 1) and return to work (n = 6). The proportion of patients who returned to work within 12 months of surgery was 84% (95% confidence interval [CI] 50–96%, I-squared = 38%, 5 studies) for gross total resection, 66% (95% CI 14–96%, I2 = 57%, 5 studies) for subtotal resection, and 31% (95% CI 4–82%, I2 = 0%, 4 studies) for partial resection. There was insufficient data on other functional outcomes for quantitative synthesis. Conclusion: A higher proportion of DLGG patients returned to work following gross total resection compared with those who had a subtotal or partial resection. Further studies with standardized assessments can clarify the association between EoR and different functional outcomes.

• Item Type: Articles
• Additional Information: Funding: MTCP was supported by a Cancer Research UK Brain Tumour Centre of Excellence Award (C157/A27589).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: El Sheikh, Mr Mustafa and Lammy, Dr Simon

Creator Roles

Elsheikh, M.: Conceptualization, Writing – original draft, Writing – review and editing, Project administration, Investigation, Formal analysis
Lammy, S.: Writing – review and editing, Supervision

• Authors: Elsheikh, M., Bridgman, E., Lavrador, J. P., Lammy, S., and Poon, M. T. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Neuro-Oncology
• Publisher: Springer
• ISSN: 0167-594X
• ISSN (Online): 1573-7373
• Published Online: 21 November 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Journal of Neuro-Oncology 160(3): 717-724
• Publisher Policy: Reproduced under a Creative Commons license