Lithgow, H. et al. (2022) Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle-damaging resistance exercise in young and older adults—the TAKEOVER study. Trials, 23, 1026. (doi: 10.1186/s13063-022-06937-y) (PMID:36539791) (PMCID:PMC9764575)
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Abstract
Background: Regular participation in resistance exercise is known to have broad-ranging health benefits and for this reason is prominent in the current physical activity guidelines. Recovery after such exercise is important for several populations across the age range and nutritional strategies to enhance recovery and modulate post-exercise physiological processes are widely studied, yet effective strategies remain elusive. Vitamin K2 supplementation has emerged as a potential candidate, and the aim of the current study, therefore, is to test the hypothesis that vitamin K2 supplementation can accelerate recovery, via modulation of the underlying physiological processes, following a bout of resistance exercise in young and older adults. Methods: The current study is a two-arm randomised controlled trial which will be conducted in 80 (40 young (≤40 years) and 40 older (≥65 years)) adults to compare post-exercise recovery in those supplemented with vitamin K2 or placebo for a 12-week period. The primary outcome is muscle strength with secondary outcomes including pain-free range of motion, functional abilities, surface electromyography (sEMG) and markers of inflammation and oxidative stress. Discussion: Ethical approval has been granted by the College of Medical Veterinary and Life Sciences Ethical Committee at the University of Glasgow (Project No 200190189) and recruitment is ongoing. Study findings will be disseminated through a presentation at scientific conferences and in scientific journals. Trial registration: ClinicialTrials.gov NCT04676958. Prospectively registered on 21 December 2020.
Item Type: | Articles |
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Additional Information: | The study is funded by a grant from Kappa Biosciences to University of Glasgow. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Celis, Dr Carlos and Gray, Professor Stuart and Ho, Dr Frederick and Mark, Professor Patrick and Lees, Jennifer and Quinn, Professor Terry and Lithgow, Dr Hannah and Johnston, Miss Lynsey |
Authors: | Lithgow, H., Johnston, L., Ho, F. K., Celis-Morales, C., Cobley, J., Raastad, T., Hunter, A. M., Lees, J. S., Mark, P. B., Quinn, T. J., and Gray, S. R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
Journal Name: | Trials |
Publisher: | BioMed Central |
ISSN: | 1745-6215 |
ISSN (Online): | 1745-6215 |
Copyright Holders: | Copyright © 2022 The Authors |
First Published: | First published in Trials 23: 1026 |
Publisher Policy: | Reproduced under a Creative Commons License |
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