Ultrahigh frequency ultrasound microbeam for biomedical applications

Lam, K. H. , Li, Y., Lee, C., Zhou, Q. and Shung, K. K. (2012) Ultrahigh frequency ultrasound microbeam for biomedical applications. In: 2012 IEEE International Ultrasonics Symposium (IUS), Dresden, Germany, 7-10 Oct 2012, pp. 1994-1997. (doi: 10.1109/ULTSYM.2012.0499)

Abstract

Several 200-MHz lithium niobate (LN) single crystal single-element press-focused ultrasonic transducers were developed for biomedical applications. Micro-particle trapping experiments were carried out to demonstrate that the acoustic device can manipulate a single microbead as small as 5 µm within the range of hundreds of micrometers in distilled water. As the result suggests that the 200-MHz microbeam device is capable of manipulating particles two-dimensionally at the cellular level, the device was used for studying red blood cell (RBC) mechanical deformation. It was found that by attaching the trapped microbead to a RBC, the RBC could be stretched by moving the trapped microbead. This preliminary result demonstrates the acoustic microbeam may be promising tool for studying the RBC membrane elastic properties.

• Item Type: Conference Proceedings
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lam, Dr Koko
• Authors: Lam, K. H., Li, Y., Lee, C., Zhou, Q., and Shung, K. K.
• College/School: College of Science and Engineering > School of Engineering > Systems Power and Energy
• Journal Name: 2012 Ieee International Ultrasonics Symposium (Ius)