Chen, R., Paeng, D.-G., Lam, K. H. , Zhou, Q., Shung, K. K., Matsuoka, N. and Humayun, M. S. (2013) In vivo sonothrombolysis of ear marginal vein of rabbits monitored with high-frequency ultrasound needle transducer. Journal of Medical and Biological Engineering, 33(1), pp. 103-110. (doi: 10.5405/jmbe.1219)
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Abstract
Ultrasound (US) is known to enhance thrombolysis when thrombolytic agents and/or microbubbles are injected into the targeted vessels. In this research, high-intensity US (1 MHz, 7 W/cm(2), 30 % duty cycle) was applied in vivo to the ear marginal vein of three rabbits which was occluded by either laser photothrombosis or thrombin, right after the injection of 0.3 similar to 0.6 cc of microbubbles (13 x 10(8) bubbles/ml of concentration) through the other ear vein without using any thrombolytic agent. To determine the effect of the sonothrombolysis, the blood flow velocity near the occlusion site in the vein was measured by a custom-made 40-MHz US needle transducer and its corresponding Doppler US system. The Doppler spectra show that the blood flow velocity recovered from total occlusion after three 10-minute high-intensity US treatments. Fluorescein angiography was employed to confirm the opening of the vessel occlusion. A control study of three rabbits with only the microbubble injection showed no recovery on the occlusion in 3 hours. The results show that the sonothrombolysis in the rabbit ear marginal vein can be achieved with microbubbles only. The results of cavitation measurements indicate that the mechanism of sonothrombolysis is probably due to the cavitation induced by the microbubbles. Without the need of applying any thrombolytic agent, high-intensity US has high potential for therapies targeting on small blood vessels.
| Item Type: | Articles |
|---|---|
| Additional Information: | Volume 33 of journal no longer available online. Follow 'other' link for web of science record. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lam, Dr Koko |
| Authors: | Chen, R., Paeng, D.-G., Lam, K. H., Zhou, Q., Shung, K. K., Matsuoka, N., and Humayun, M. S. |
| College/School: | College of Science and Engineering > School of Engineering > Systems Power and Energy |
| Journal Name: | Journal of Medical and Biological Engineering |
| Publisher: | Springer |
| ISSN: | 1609-0985 |
| ISSN (Online): | 2199-4757 |
| Related URLs: |
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