In vivo intravascular photoacoustic imaging at a high speed of 100 frames per second

Xie, Z. et al. (2020) In vivo intravascular photoacoustic imaging at a high speed of 100 frames per second. Biomedical Optics Express, 11(11), pp. 6721-6731. (doi: 10.1364/BOE.405792) (PMID:33282520) (PMCID:PMC7687943)

Abstract

Intravascular photoacoustic (IVPA) imaging technology enables the visualization of pathological characteristics (such as inflammation activities, lipid deposition) of the artery wall. Blood flushing is a necessary step in improving the imaging quality in in vivo IVPA imaging. But the limited imaging speed of the systems stretches their flushing time, which is an important obstacle of their clinical translations. In this paper, we report an improvement in IVPA/IVUS imaging speed to 100 frames per second. The high-speed imaging is demonstrated in rabbit in vivo, visualizing the nanoparticles accumulated on abdominal aorta wall at the wavelength of 1064 nm, in real time display. Blood flushing in vivo improves the IVPA signal-noise-ratio by around 3.5 dB. This study offers a stable, efficient and easy-to-use tool for instantaneous disease visualization and disease diagnosis in research and forwards IVPA/IVUS imaging technology towards clinical translations.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lam, Dr Koko
• Authors: Xie, Z., Shu, C., Yang, D., Chen, H., Chen, C., Dai, G., Lam, K. H., Zhang, J., Wang, X., Sheng, Z., Gao, D., Liu, C., Song, L., and Gong, X.
• College/School: College of Science and Engineering > School of Engineering > Systems Power and Energy
• Journal Name: Biomedical Optics Express
• Publisher: Optica Publishing Group
• ISSN: 2156-7085
• ISSN (Online): 2156-7085
• Published Online: 27 October 2020

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