Leng, J. et al. (2021) Multi-spectral intravascular photoacoustic/ultrasound/optical coherence tomography tri-modality system with a fully-integrated 0.9-mm full field-of-view catheter for plaque vulnerability imaging. Biomedical Optics Express, 12(4), pp. 1934-1946. (doi: 10.1364/BOE.420724) (PMID:33996208) (PMCID:PMC8086469)
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Abstract
Myocardial infarctions are most often caused by the so-called vulnerable plaques, usually featured as non-obstructive lesions with a lipid-rich necrotic core, thin-cap fibroatheroma, and large plaque size. The identification and quantification of these characteristics are the keys to evaluate plaque vulnerability. However, single modality intravascular methods, such as intravascular ultrasound, optical coherence tomography and photoacoustic, can hardly achieve all the comprehensive information to satisfy clinical needs. In this paper, for the first time, we developed a novel multi-spectral intravascular tri-modality (MS-IVTM) imaging system, which can perform 360° continuous rotation and pull-backing with a 0.9-mm miniature catheter and achieve simultaneous acquisition of both morphological characteristics and pathological compositions. Intravascular tri-modality imaging demonstrates the ability of our MS-IVTM system to provide macroscopic and microscopic structural information of the vessel wall, with identity and quantification of lipids with multi-wavelength excitation. This study offers clinicians and researchers a novel imaging tool to facilitate the accurate diagnosis of vulnerable atherosclerotic plaques. It also has the potential of clinical translations to help better identify and evaluate high-risk plaques during coronary interventions.
Item Type: | Articles |
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Additional Information: | National Natural Science Foundation of China (61975226, 61705250); National Key Research and Development Program of China (2018YFC0116302); Scientific Instruments Funding of Chinese Academy of Sciences (YJKYYQ20190077); CAS Key Laboratory of Health Informatics (2011DP173015); Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology (2020B121201010); Hong Kong Research Impact Fund (R5029-19); Innovation and Technology Fund (ITF/082/18); Shenzhen Municipal Science and Technology Innovation Council (ZDSY20130401165820357). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Lam, Dr Koko |
Authors: | Leng, J., Zhang, J., Li, C., Shu, C., Wang, B., Lin, R., Liang, Y., Wang, K., Shen, L., Lam, K.H., Xie, Z., Gong, X., Ge, J., and Song, L. |
College/School: | College of Science and Engineering > School of Engineering > Systems Power and Energy |
Journal Name: | Biomedical Optics Express |
Publisher: | Optical Society of America |
ISSN: | 2156-7085 |
ISSN (Online): | 2156-7085 |
Published Online: | 09 March 2021 |
Copyright Holders: | Copyright © 2021 Optical Society of America |
First Published: | First published in Biomedical Optics Express 12(4):1934-1946 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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