Newman, E., Khoo, T.C., Patterson, J., Cavanagh, J. , Pimlott, S. , Grosset, K.A. and Grosset, D.G. (2012) Serotonergic Function in Early Parkinson's Disease With and Without Depression: A Pilot Study. Association of British Neurologists Annual Meeting 2011, Newcastle, UK, 2011. (doi: 10.1136/jnnp-2011-301993.158)
Full text not currently available from Enlighten.
Abstract
Introduction The role of the serotonergic system in Parkinson's disease (PD) depression is unclear. [123I] β-CIT, a single photon emission computed tomography (SPECT) radioligand, binds differentially to both dopamine and serotonin transporters (DAT, SERT). Aim To assess the relationship between SERT activity and depressive symptoms in newly-diagnosed, antiparkinson drug-naïve PD patients with and without depression. Methods Drug-naïve patients with a new clinical diagnosis of PD were assessed using the Unified Parkinson's Disease Rating Scale (UPDRS), Hamilton Depression Rating Scale (HAM-17), Montgomery-Asberg Depression Rating Scale (MADRS) and Hospital Anxiety and Depression Scale (HADS) and were imaged with [123I]β-CIT SPECT. Results 10 patients (mean 59.0 (7.4) years) were recruited. Four patients were depressed (PD+D) and six were not (PD−D). No significant differences in DAT or SERT uptake were observed between PD+D and PD−D patients. No significant correlation was found between SERT uptake and depression scores. In PD-D patients significant positive correlation was found between SERT uptake and DAT uptake in multiple regions (midbrain SERT and right caudate DAT, r=0.968, p=0.001; midbrain SERT and right putamen DAT, r=0.953, p=0.003) but no such correlation was found in PD+D patients. Conclusion There was no correlation between depressive symptoms and serotonergic function in newly diagnosed PD cases.
| Item Type: | Conference or Workshop Item |
|---|---|
| Additional Information: | Abstract - Available in Journal of Neurology, Neurosurgery & Psychiatry 83(3). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Grosset, Professor Donald and Pimlott, Dr Sally and Cavanagh, Professor Jonathan and Khoo, Dr Teng Cheng and Grosset, Dr Katherine and Newman, Dr Edward |
| Authors: | Newman, E., Khoo, T.C., Patterson, J., Cavanagh, J., Pimlott, S., Grosset, K.A., and Grosset, D.G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
| Journal Name: | Journal of Neurology Neurosurgery and Psychiatry |
| ISSN: | 0022-3050 |
| Related URLs: |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details