Consequences of 18F-FDG Extravasation

Findlay, C. , Allwood-Spires, S., McKeown, C. and Gillen, G. (2016) Consequences of 18F-FDG Extravasation. Annual Congress of the European Association of Nuclear Medicine 2016, Barcelona, Spain, 15-19 Oct 2016. pp. 1-734. (doi: 10.1007/s00259-016-3484-4)

Abstract

Aim Extravasation of 18F-FDG can cause image artefacts and localised tissue dose, potentially leading to tissue necrosis. A retrospective analysis of 25 patients who had tissued injections was made to quantify activity and localised tissue dose to the injection site. Methods Twenty-five patients with tissued injections were analysed. The radioactivity present at the extravasation site was quantified and tissue dose calculated using the specific dose factor for 18F. Results Radioactivity within the injection site ranged from 0.07MBq to 129MBq. Tissue doses ranged between 6mGy to 608mGy. Of the 25 cases, 8 had more than 10% of the injected activity at the extravasation site. In most cases where a high activity was tissued, the activity was spread over a large volume and so the localised tissue dose received was not high. The highest dose received from a tissued injection from this sample, estimated at 608mGy, is well below the level at which erythema is likely to occur. Deterministic effects of radiation on the skin are expected to occur from a dose of 2Gy upwards [1]. Conclusions Evidence from this patient sample has shown that despite what can sometimes be striking appearances on patient images, the dose from 18F-FDG tissued injections is unlikely to result in tissue necrosis

• Item Type: Conference or Workshop Item
• Additional Information: Abstract - available in European Journal of Nuclear Medicine and Molecular Imaging 43(suppl 1): S442
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Findlay, Dr Caroline and McKeown, Dr Clare and Gillen, Dr Gerry
• Authors: Findlay, C., Allwood-Spires, S., McKeown, C., and Gillen, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: European Journal of Nuclear Medicine and Molecular Imaging, Barcelona, 15-19 Oct, 2016
• Publisher: Springer Science and Business Media LLC
• ISSN: 1619-7089