Acetylcholine receptors in mesenchymal stem cells

Alqahtani, S., Butcher, M. C., Ramage, G. , Dalby, M. J. , McLean, W. and Nile, C. J. (2023) Acetylcholine receptors in mesenchymal stem cells. Stem Cells and Development, 32(3-4), pp. 47-59. (doi: 10.1089/scd.2022.0201) (PMID:36355611)

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Mesenchymal stem cells (MSCs) are well known for their regenerative potential. Despite the fact that the ability of MSCs to proliferate and differentiate has been studied extensively, there still remains much to learn about the signalling mechanisms and pathways which control proliferation and influence differentiation phenotype. In recent years, there has been growing evidence for the utility of non-neuronal cholinergic signalling systems and that acetylcholine (ACh) plays an important, ubiquitous, role in cell-to-cell communication. Indeed, cholinergic signalling is hypothesised to occur in stem cells and ACh synthesis, as well as ACh receptor (AChR) expression, has been identified in several stem cell populations; including MSCs. Furthermore, AChRs have been found to influence MSC regenerative potential. In humans, there are two major classes of AChRs, muscarinic AChRs and nicotinic AChRs, with each class possessing several subtypes or subunits. In this review, the expression and function of AChRs in different types of MSC will be summarised with the aim of highlighting how AChRs play a pivotal role in regulating MSC regenerative function.

Item Type:Articles
Additional Information:MCB was funded by GlaxoSmithKline Consumer Healthcare and the BBSRC Industrial GlaxoSmithKline CASE PhD studentship (BB/V509541/1).
Glasgow Author(s) Enlighten ID:Butcher, Mr Mark and Ramage, Professor Gordon and Alqahtani, Saeed Saad H and Nile, Dr Christopher and Mclean, Professor William and Dalby, Professor Matthew
Authors: Alqahtani, S., Butcher, M. C., Ramage, G., Dalby, M. J., McLean, W., and Nile, C. J.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:Stem Cells and Development
Publisher:Mary Ann Liebert
ISSN (Online):1557-8534
Published Online:10 November 2022
Copyright Holders:Copyright © 2022 Mary Ann Leibert, Inc.
First Published:First published in Stem Cells and Development 32(3-4): 47-59
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
312246Using Big Data to Model the Maintenance of Health in the Human Oral CavityGordon RamageBiotechnology and Biological Sciences Research Council (BBSRC)BB/V509541/1Med - Dental School