Hargrave, K. E., MacLeod, M. K.L. and Worrell, J. C. (2022) Antigen presenting cells: professionals, amateurs, and spectators in the 'long game' of lung immunity. International Journal of Biochemistry and Cell Biology, 153, 106331. (doi: 10.1016/j.biocel.2022.106331) (PMID:36368596)
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Abstract
The lung is frequently and repeatedly exposed to invading pathogens and thus requires constant immunosurveillance. Professional antigen presenting cells (APCs), including dendritic cells, engulf invading pathogens and present their peptides via major histocompatibility complexes (MHC) I and II, to CD8 or CD4 T cells. Epithelial cells and stromal cells (including fibroblasts) provide more than structural support, they are increasingly recognised as key players in the immune response, acting as non-professional APCs through interactions with antigen experienced T cells that migrate to the lung. The importance of the contributions of non-professional and professional APCs to T cell function in vivo, is currently unclear. This review summarises the roles of professional and non-professional APCs in lung immunity, at the steady state and following viral insult, with particular emphasis on their ability to interact with and influence T cells.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Worrell, Dr Julie and Macleod, Dr Megan and Hargrave, Dr Kerrie |
| Authors: | Hargrave, K. E., MacLeod, M. K.L., and Worrell, J. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | International Journal of Biochemistry and Cell Biology |
| Publisher: | Elsevier |
| ISSN: | 1357-2725 |
| ISSN (Online): | 1878-5875 |
| Published Online: | 08 November 2022 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in International Journal of Biochemistry and Cell Biology 153: 106331 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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