MicroRNAs’ crucial role in salivary gland cancers’ onset and prognosis

Bocchetti, M. et al. (2022) MicroRNAs’ crucial role in salivary gland cancers’ onset and prognosis. Cancers, 14(21), 5304. (doi: 10.3390/cancers14215304) (PMID:36358723) (PMCID:PMC9657964)

Abstract

Simple Summary: Salivary gland cancers are incredibly heterogeneous, both in the physical onset and in the aggressiveness. Setting up a novel diagnostic and prognostic detection method based on the noninvasive microRNAs’ profiling might represent a goal for the clinical management of those particular malignancies, saving precious time for the patients. Abstract: Salivary gland cancer (SGC) is an uncommon and heterogeneous disease that accounts for around 8.5% of all head and neck cancers. MicroRNAs (miRNAs) consist of a class of highly conserved, short, single-stranded segments (18–25 nucleotides) of noncoding RNA that represent key gene-transcription regulators in physiological and pathological human conditions. However, their role in SGC development and progression is not completely clear. This review aims to compile and summarize the recent findings on the topic, focusing on the prognostic and diagnostic value of the major modulated and validated microRNAs in SGC. Their differential expression could possibly aid the clinician in delivering an early diagnosis, therapeutic strategy and precision medicine.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ferraro, Mrs Maria Grazia
• Authors: Bocchetti, M., Grisolia, P., Melisi, F., Ferraro, M. G., De Luca, P., Camaioni, A., Falco, M., Abate, M., Misso, G., Alfano, R., Accardo, N., Oliva, F., Cossu, A. M., Caraglia, M., Scrima, M., and Ricciardiello, F.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Cancers
• Publisher: MDPI
• ISSN: 2072-6694
• ISSN (Online): 2072-6694
• Published Online: 28 October 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Cancers 14(21): 5304
• Publisher Policy: Reproduced under a Creative Commons License