Marland, J. R.K., Tsiamis, A., Hoare, D., Ledesma Lopez, P. G., Neale, S. L. , Mercer, J. R. and Mitra, S. (2023) Towards synthetic vascular graft monitoring using a flip-chip-on-flex impedance spectroscopy sensor. IEEE Sensors Journal, 23(1), pp. 88-96. (doi: 10.1109/JSEN.2022.3220022)
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Abstract
Synthetic vascular grafts are used in a wide range of clinical applications. However, they can become prone to occlusion over time, due to growth of vascular smooth muscle cells (VSMC). This phenomenon is associated with graft failure. Here, we describe novel techniques for packaging and integration of a miniature sensor of VSMC growth. The sensor was based on a microfabricated array of interdigitated platinum electrodes on a silicon substrate. It was assembled using flip-chip-on-flex technology to create a low-profile package that can be manufactured using industry-standard tools and is suitable for integration with a synthetic vascular graft. The packaged sensor responded to changes in solution impedance, and accurately detected growth of VSMC in vitro. We also demonstrated successful proof-of-concept integration of the sensor with a custom synthetic graft. Together these technologies have the potential to allow early detection of VSMC growth prior to graft occlusion, enabling more timely and effective clinical interventions to be made.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mitra, Dr Srinjoy and Hoare, Dr Daniel and Mercer, Dr John and Neale, Professor Steven |
| Authors: | Marland, J. R.K., Tsiamis, A., Hoare, D., Ledesma Lopez, P. G., Neale, S. L., Mercer, J. R., and Mitra, S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Science and Engineering > School of Engineering College of Science and Engineering > School of Engineering > Systems Power and Energy |
| Journal Name: | IEEE Sensors Journal |
| Publisher: | IEEE |
| ISSN: | 1530-437X |
| ISSN (Online): | 1558-1748 |
| Published Online: | 10 November 2022 |
| Copyright Holders: | Copyright © 2022 IEEE |
| First Published: | First published in IEEE Sensors Journal 23(1): 88-96 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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