Towards synthetic vascular graft monitoring using a flip-chip-on-flex impedance spectroscopy sensor

Marland, J. R.K., Tsiamis, A., Hoare, D., Ledesma Lopez, P. G., Neale, S. L. , Mercer, J. R. and Mitra, S. (2023) Towards synthetic vascular graft monitoring using a flip-chip-on-flex impedance spectroscopy sensor. IEEE Sensors Journal, 23(1), pp. 88-96. (doi: 10.1109/JSEN.2022.3220022)

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Abstract

Synthetic vascular grafts are used in a wide range of clinical applications. However, they can become prone to occlusion over time, due to growth of vascular smooth muscle cells (VSMC). This phenomenon is associated with graft failure. Here, we describe novel techniques for packaging and integration of a miniature sensor of VSMC growth. The sensor was based on a microfabricated array of interdigitated platinum electrodes on a silicon substrate. It was assembled using flip-chip-on-flex technology to create a low-profile package that can be manufactured using industry-standard tools and is suitable for integration with a synthetic vascular graft. The packaged sensor responded to changes in solution impedance, and accurately detected growth of VSMC in vitro. We also demonstrated successful proof-of-concept integration of the sensor with a custom synthetic graft. Together these technologies have the potential to allow early detection of VSMC growth prior to graft occlusion, enabling more timely and effective clinical interventions to be made.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mitra, Dr Srinjoy and Hoare, Dr Daniel and Mercer, Dr John and Neale, Professor Steven
Authors: Marland, J. R.K., Tsiamis, A., Hoare, D., Ledesma Lopez, P. G., Neale, S. L., Mercer, J. R., and Mitra, S.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Science and Engineering > School of Engineering
College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:IEEE Sensors Journal
Publisher:IEEE
ISSN:1530-437X
ISSN (Online):1558-1748
Published Online:10 November 2022
Copyright Holders:Copyright © 2022 IEEE
First Published:First published in IEEE Sensors Journal 23(1): 88-96
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
304979University of Glasgow NPIF 2018Heather LambieEngineering and Physical Sciences Research Council (EPSRC)EP/S515401/1S&E - Graduate School
301576ISFC Wave 1: High Energy Density Capacitors Manufactured with Optoelectronic Tweezers (CapOET)Steven NealeEngineering and Physical Sciences Research Council (EPSRC)EP/R020892/1ENG - Systems Power & Energy