LTP-like synaptic efficacy changes following electroconvulsive stimulation

Stewart, C., Jeffery, K. and Reid, I. (1994) LTP-like synaptic efficacy changes following electroconvulsive stimulation. NeuroReport, 5(9), pp. 1041-1044. (doi: 10.1097/00001756-199405000-00006) (PMID:8080955)

Full text not currently available from Enlighten.

Abstract

SYNAPTIC plasticity is thought to represent a mechanism for memory formation. Memory disturbances commonly follow electroconvulsive therapy (ECT) for depression. Accordingly, we examined the development and duration of the effects of electroconvulsive stimulation (ECS) on hippocampal synaptic plasticity in rats. Daily recording of field potentials during 10 spaced ECS revealed an increase in the dentate gyrus evoked response, reaching a maximum after the fifth seizure. In a second experiment, an identical ECS series substantially reduced the degree to which electrically induced synaptic changes (long-term potentiation—LTP) could be elicited under anaesthesia for up to 40 days. These findings suggest that ECS induces LTP-like long-lasting synaptic changes which may underlie the neuropsychological sequelae of ECT treatment in humans.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jeffery, Professor Kate
Authors: Stewart, C., Jeffery, K., and Reid, I.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:NeuroReport
Publisher:Lippincott Williams & Wilkins
ISSN:0959-4965
ISSN (Online):1473-558X

University Staff: Request a correction | Enlighten Editors: Update this record