The place-cell representation of volumetric space in rats

Grieves, R. M., Jedidi-Ayoub, S., Mishchanchuk, K., Liu, A., Renaudineau, S. and Jeffery, K. J. (2020) The place-cell representation of volumetric space in rats. Nature Communications, 11, 789. (doi: 10.1038/s41467-020-14611-7) (PMID:32034157) (PMCID:PMC7005894)

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Abstract

Place cells are spatially modulated neurons found in the hippocampus that underlie spatial memory and navigation: how these neurons represent 3D space is crucial for a full understanding of spatial cognition. We wirelessly recorded place cells in rats as they explored a cubic lattice climbing frame which could be aligned or tilted with respect to gravity. Place cells represented the entire volume of the mazes: their activity tended to be aligned with the maze axes, and when it was more difficult for the animals to move vertically the cells represented space less accurately and less stably. These results demonstrate that even surface-dwelling animals represent 3D space and suggests there is a fundamental relationship between environment structure, gravity, movement and spatial memory.

Item Type:Articles
Additional Information:This work was supported by a grant from Wellcome (103896AIA) to K.J.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jeffery, Dr Kate
Authors: Grieves, R. M., Jedidi-Ayoub, S., Mishchanchuk, K., Liu, A., Renaudineau, S., and Jeffery, K. J.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Nature Communications
Publisher:Nature Research
ISSN:2041-1723
ISSN (Online):2041-1723
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Nature Communications 11: 789
Publisher Policy:Reproduced under a Creative Commons License

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