The place-cell representation of volumetric space in rats

Grieves, R. M., Jedidi-Ayoub, S., Mishchanchuk, K., Liu, A., Renaudineau, S. and Jeffery, K. J. (2020) The place-cell representation of volumetric space in rats. Nature Communications, 11, 789. (doi: 10.1038/s41467-020-14611-7) (PMID:32034157) (PMCID:PMC7005894)

Abstract

Place cells are spatially modulated neurons found in the hippocampus that underlie spatial memory and navigation: how these neurons represent 3D space is crucial for a full understanding of spatial cognition. We wirelessly recorded place cells in rats as they explored a cubic lattice climbing frame which could be aligned or tilted with respect to gravity. Place cells represented the entire volume of the mazes: their activity tended to be aligned with the maze axes, and when it was more difficult for the animals to move vertically the cells represented space less accurately and less stably. These results demonstrate that even surface-dwelling animals represent 3D space and suggests there is a fundamental relationship between environment structure, gravity, movement and spatial memory.

• Item Type: Articles
• Additional Information: This work was supported by a grant from Wellcome (103896AIA) to K.J.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Jeffery, Professor Kate
• Authors: Grieves, R. M., Jedidi-Ayoub, S., Mishchanchuk, K., Liu, A., Renaudineau, S., and Jeffery, K. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Nature Communications
• Publisher: Nature Research
• ISSN: 2041-1723
• ISSN (Online): 2041-1723
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in Nature Communications 11: 789
• Publisher Policy: Reproduced under a Creative Commons License