AQP1 expression in the proximal tubule of diabetic rat kidney.

Seyahian, E. A., Cacciagiu, L., Damiano, A. E. and Zotta, E. (2020) AQP1 expression in the proximal tubule of diabetic rat kidney. Heliyon, 6, e03192. (PMCID:PMC6956755)

Abstract

Polyuria is a hallmark symptom and the first clinical manifestation of diabetes mellitus (DM). The glucose that remains in renal tubules was proposed to produce an osmotic effect resulting in polyuria. Although water is reabsorbed in proximal tubules through an aquaporin-1 (AQP1) dependent mechanism, AQP1 role in the genesis of polyuria is unknown. AQP1 expression was studied in a rat model of Type-1 DM at 15-days and 5-months of evolution. A different AQP1 expression pattern was found in both experimental groups, with no changes in AQP1 localization, suggesting that changes in AQP1 may be involved in the development of polyuria.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Seyahian, Dr Abril
• Authors: Seyahian, E. A., Cacciagiu, L., Damiano, A. E., and Zotta, E.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment
• Journal Name: Heliyon
• Publisher: Elsevier Cell Press
• ISSN: 2405-8440
• ISSN (Online): 2405-8440
• Copyright Holders: Copyright © 2020 Published by Elsevier Ltd.
• First Published: First published in Heliyon 6:e03192
• Publisher Policy: Reproduced under a Creative Commons licence