Exhaled nitric oxide and pulmonary artery pressures during graded ascent to high altitude

Donnelly, J., Cowan, D. C. , Yeoman, D. J., Lucas, S. J. E., Herbison, G. P., Thomas, K. N., Ainslie, P. N. and Taylor, D. R. (2011) Exhaled nitric oxide and pulmonary artery pressures during graded ascent to high altitude. Respiratory Physiology and Neurobiology, 177(3), pp. 213-217. (doi: 10.1016/j.resp.2011.04.008) (PMID:21515414)

Abstract

Nitric oxide (NO) is a potent vasodilator that regulates pulmonary vascular tone. During ascent to high altitude, pulmonary vascular tone increases leading to pulmonary hypertension. To explore the mechanisms underpinning this effect, we investigated the relationship between exhaled NO (PENO; nmHg) and pulmonary artery systolic pressure (PASP; mmHg) in 11 healthy adults during hypoxic challenge at sea level [with oxygen saturations (SPO2) of 80% and 90%] and at intervals during graded ascent to 5050 m. During normobaric hypoxia, PASP progressively increased from 22.7 mmHg to 33.5 mmHg (p = 0.006), whilst PENO remained unchanged. In contrast, during ascent to high altitude, PASP increased progressively from 22.7 mmHg to 39.1 mmHg (p < 0.001), but PENO decreased from 18.8 nmHg to 9.0 nmHg (p < 0.001). However, after appropriate adjustments, PENO had no significant effect on PASP at altitude (p = 0.309). These findings indicate that although exhaled NO decreases with altitude, it does not appear to be a major contributor to hypoxic pulmonary vasoconstriction.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cowan, Douglas
• Authors: Donnelly, J., Cowan, D. C., Yeoman, D. J., Lucas, S. J. E., Herbison, G. P., Thomas, K. N., Ainslie, P. N., and Taylor, D. R.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Respiratory Physiology and Neurobiology
• Publisher: Elsevier
• ISSN: 1569-9048
• ISSN (Online): 1878-1519