Obstructive sleep apnoea syndrome and weight loss: review

Cowan, D. C. and Livingston, E. (2012) Obstructive sleep apnoea syndrome and weight loss: review. Sleep Disorders, 2012, 163296. (doi: 10.1155/2012/163296) (PMID:23471145) (PMCID:PMC3581237)

Abstract

Obstructive sleep apnoea (OSA) syndrome is common, and obesity is a major risk factor. Increased peripharyngeal and central adiposity result in increased pharyngeal collapsibility, through increased mechanical loading around the upper airway, reduced tracheal traction on the pharynx, and reduced neuromuscular activity, particularly during sleep. Significant and sustained weight loss, if achieved, is likely to be a useful therapeutic option in the management of OSA and may be attempted by behavioural, pharmacological, and surgical approaches. Behavioural therapy programs that focus on aspects such as dietary intervention, exercise prescription patients and general lifestyle counselling have been tested. Bariatric surgery is an option in the severely obese when nonsurgical measures have failed, and laparoscopic adjustable gastric banding and Roux-en-Y gastric bypass are the most commonly employed techniques in the United Kingdom. Most evidence for efficacy of surgery comes from cohort studies. The role of sibutramine in OSA in the obese patients has been investigated, however, there are concerns regarding associated cardiovascular risk. In this paper the links between obesity and OSA are discussed, and the recent studies evaluating the behavioural, pharmacological and surgical approaches to weight loss in OSA are reviewed.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cowan, Douglas
• Authors: Cowan, D. C., and Livingston, E.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Sleep Disorders
• Publisher: Hindawi
• ISSN: 2090-3545
• ISSN (Online): 2090-3553
• Copyright Holders: Copyright © 2012 D. C. Cowan and E. Livingston
• First Published: First published in Sleep Disorders 2012:163296
• Publisher Policy: Reproduced under a Creative Commons licence