Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

Heaney, L. G. et al. (2016) Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK). Thorax, 71(2), pp. 187-189. (doi: 10.1136/thoraxjnl-2015-207326) (PMID:26205878) (PMCID:PMC4752622)

Abstract

The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite biomarker strategy to optimise CS dose; this will also address what proportion of patients with severe asthma have persistent symptoms without eosinophilic airways inflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies.

• Item Type: Articles
• Additional Information: Funding: Medical Research Council (MR/M016579/1) and Industrial Partner project contributions.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cowan, Douglas
• Authors: Heaney, L. G., Djukanovic, R., Woodcock, A., Walker, S., Matthews, J. G., Pavord, I. D., Bradding, P., Niven, R., Brightling, C. E., Chaudhuri, R., Arron, J. R., Choy, D. F., Cowan, D., Mansur, A., Menzies-Gow, A., Adcock, I., Chung, K. F., Corrigan, C., Coyle, P., Harrison, T., Johnston, S., Howarth, P., Lordan, J., Sabroe, I., Bigler, J., Smith, D., Catley, M., May, R., Pierre, L., Stevenson, C., Crater, G., Keane, F., Costello, R. W., Hudson, V., Supple, D., and Hardman, T.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Thorax
• Publisher: BMJ Publishing Group
• ISSN: 0040-6376
• ISSN (Online): 1468-3296
• Copyright Holders: Copyright © 2016 The Authors
• First Published: First published in Thorax 71(2):187-189
• Publisher Policy: Reproduced under a Creative Commons licence