Fares, M. and Brennan, B. (2022) Virus-host interactions during tick-borne bunyavirus infection. Current Opinion in Virology, 57, 101278. (doi: 10.1016/j.coviro.2022.101278) (PMID:36375406)
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Abstract
The Bunyavirales order is the largest grouping of RNA viruses, comprising emerging and re-emerging human, plant and animal pathogens. Bunyaviruses have a global distribution and many members of the order are transmitted by arthropods. They have evolved a plethora of mechanisms to manipulate the regulatory processes of the infected cell to facilitate their own replicative cycle, in hosts of disparate phylogenies. Interest in virus-vector interactions is growing rapidly. However, current understanding of tick-borne bunyavirus cellular interaction is heavily biased to studies conducted in mammalian systems. In this short review, we summarise current understandings of how tick-borne bunyaviruses utilise major cellular pathways (innate immunity, apoptosis and RNAi responses) in mammalian or tick cells to facilitate virus replication.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Brennan, Dr Benjamin and Fares, Dr Mazigh |
| Authors: | Fares, M., and Brennan, B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Current Opinion in Virology |
| Publisher: | Elsevier |
| ISSN: | 1879-6257 |
| ISSN (Online): | 1879-6265 |
| Published Online: | 11 November 2022 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in Current Opinion in Virology 57: 101278 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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