Thirumurugan, S. et al. (2022) Angiopep-2-decorated titanium-alloy core-shell magnetic nanoparticles for nanotheranostics and medical imaging. Nanoscale, 14(39), pp. 14789-14800. (doi: 10.1039/d2nr03683e) (PMID:36184995)
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282444.pdf - Accepted Version 1MB |
Abstract
The poor permeability of therapeutic agents across the blood–brain barrier and blood-tumor barrier is a significant barrier in glioma treatment. Low-density lipoprotein receptor-related protein (LRP-1) recognises a dual-targeting ligand, angiopep-2, which is overexpressed in the BBB and gliomas. Here, we have synthesized Ti@FeAu core–shell nanoparticles conjugated with angiopep-2 (Ti@FeAu–Ang nanoparticles) to target glioma cells and treat brain cancer via hyperthermia produced by a magnetic field. Our results confirmed that Ti@FeAu core–shell nanoparticles were superparamagnetic, improved the negative contrast effect on glioma, and exhibited a temperature elevation of 12° C upon magnetic stimulation, which implies potential applications in magnetic resonance imaging (MRI) and hyperthermia-based cancer therapy. Angiopep-2-decorated nanoparticles exhibited higher cellular uptake by C6 glioma cells than by L929 fibroblasts, demonstrating selective glioma targeting and improved cytotoxicity up to 85% owing to hyperthermia produced by a magnetic field. The in vivo findings demonstrated that intravenous injection of Ti@FeAu–Ang nanoparticles exhibited a 10-fold decrement in tumor volume compared to the control group. Furthermore, immunohistochemical analysis of Ti@FeAu–Ang nanoparticles showed that coagulative necrosis of tumor tissues and preliminary safety analysis highlighted no toxicity to the haematological system, after Ti@FeAu–Ang nanoparticle-induced hyperthermia treatment.
Item Type: | Articles |
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Additional Information: | The authors are grateful for the financial support provided by the Ministry of Science and Technology of Taiwan (MOST 107-2221-E-027-014; MOST 108-2628-E-027-003-MY3), part of the Development and Reform Commission of Jilin Province (2017C059-5), and the Science and Technology Department of Jilin Province (20200401091GX). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Dhawan, Dr Udesh |
Authors: | Thirumurugan, S., Dash, P., Liu, X., Tseng, Y.-Y., Huang, W.-J., Li, Y., Zhao, G., Lin, C., Murugan, K., Dhawan, U., and Chung, R.-J. |
College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
Journal Name: | Nanoscale |
Publisher: | Royal Society of Chemistry |
ISSN: | 2040-3364 |
ISSN (Online): | 2040-3372 |
Published Online: | 12 September 2022 |
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